Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction.

This study reported that obese patients with the Metabolic Syndrome were characterized by significantly lower adiponectin levels and higher TNF-alpha concentrations compared with equally obese patients not having the Metabolic Syndrome. After a weight loss period of 4-6 weeks, although marked reductions were observed for glucose, insulin, leptin and triglyceride levels, no significant changes were noted for adiponectin and TNF-alpha concentrations.

Author(s) :
Xydakis AM, Case CC, Jones PH, Hoogeveen RC, Liu MY, Smith EO, Nelson, KW, Ballantyne CM.

Reference :
J Clin Endocrinol Metab 89:2697-2703, 2004.

Pubmed reference :
PMID: 15181044