Alanine aminotransferase as an indicator of future metabolic derangements in a population-based study
Document Actions
Transversal studies suggest that abnormalities in liver enzymes are associated with individual components of the metabolic, such as obesity and dyslipidaemia, as well as with non-alcoholic fatty liver. In a population-based study, the association of alanine aminotransferase (ALT) with the 6-year risk of metabolic syndrome (ATP III criteria) was investigated in 1097 Caucasian men and women from the Hoorn register, 50 to 75 years of age, using logistic regression analysis. During a mean follow-up of 6.4 years, 226 (20.6%) subjects developed the metabolic syndrome. After adjusting for age, sex, alcohol intake and follow-up duration, the odds ratio (OR) for developing the metabolic syndrome was 2.25 for subjects in the upper tertile of ALT compared with those in the lower tertile. This association remained robust (OR, 1.62) even after adjusting for all individual components of the metabolic syndrome features at baseline. At follow-up, ALT was significantly associated with fasting plasma glucose only.
Abstract
