Serum concentrations of uric acid strongly associated with the prevalence of the metabolic syndrome in US children and adolescents
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This study was aimed to investigate the association between concentrations of uric acid and the metabolic syndrome in a nationally representative sample of US children and adolescents. To this end, a cross-sectional analysis of 1370 subjects of both sexes aged 12 to 17 years was performed using data from the National Health and Nutrition Examination Survey 1999-2002. Uric acid levels were strongly associated with the prevalence of the metabolic syndrome and with several of its components. Among participants in the lowest quartile of serum uric acid concentration, the prevalence of the metabolic syndrome was <1%, in the second quartile 3.7%, in the third quartile 10.3% and in the highest quartile 21.1%. After adjusting for age, sex, race or ethnicity, and concentrations of C-reactive protein, the odds ratios were 5.80 for subjects in the third quartile and 14.79 for subjects in the top quartile compared with those in the lowest two quartiles of uric acid together.
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