Serum uric acid linked to risk factors of metabolic syndrome except for blood glucose

A total of 470 subjects from Taiwan were recruited to investigate the relationship between serum uric acid and risk factors associated with metabolic syndrome and to explore the association between serum uric acid, insulin resistance and serum leptin levels in the presence of a metabolic syndrome. Of the 144 subjects with hyperuricaemia, 115 (24.5%) had metabolic syndrome. Patients of the hyperuricaemia group had increased body mass index, waist-to-hip ratio, triglyceride (Tg) levels, greater hypertension and lower high-density lipoprotein. Furthermore, in patients with hyperuricaemia there was an elevation of leptin level, immunoreactive insulin (IRI) and HOMA-IR. Uric acid appeared to be better correlated with Tg, blood pressure, obesity, immunoreactive insulin, and HOMA-IR, but did not correlate with leptin and blood glucose levels. Thus, serum uric acid appears to be significantly related to risk factors of metabolic syndrome, but for fasting blood glucose.

Abstract

Keywords:
Diabetes – HOMA – Hypertension – Insulin resistance – Leptin – NCEP ATP III definition – Uric acid – Waist-to-hip ratio