Association between total cholesterol and major cardiovascular diseases in the Asia-Pacific region
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For this study, data of 30 cohort studies from the Asia-Pacific region were used in order to investigate the association between total cholesterol and major cardiovascular diseases among patients with and without diabetes. A total of 333,533 subjects were followed-up over a median period of 4.0 years for fatal and non-fatal cardiovascular event. Cox proportional model analysis revealed that total cholesterol was positively associated with coronary heart disease (CHD) and ischaemic stroke and negatively associated with haemorrhagic stroke, similarly among participants with or without diabetes. Each 1 mmol/L increase above the “usual” level for total cholesterol was associated with greater risk for CHD of 41% among subjects with diabetes versus 42% among patients without diabetes. The corresponding figures for ischaemic stroke were 23% versus 31%. Based on these findings, the authors conclude that total cholesterol was associated with similarly increased risk of cardiovascular events in subjects with or without diabetes, supporting aggressive lowering of total cholesterol and LDL-cholesterol for primary or secondary prevention of cardiovascular events.
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