Higher concentration of oxidized low-density lipoprotein associated with incidental metabolic syndrome
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The aim of this study was to investigate the longitudinal association of oxidized low-density lipoprotein (LDL) and incident metabolic syndrome (NCEP ATP III definition) in the general community. To this end, 1889 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study who were 18-30 years at the time of recruitment and were seen both at year 15 and year 20 examinations were studied. At the 20-year follow-up, incident metabolic syndrome was diagnosed in 12.9% of participants who did not have metabolic syndrome at the 15-year follow-up. After adjusting for known risk factors and LDL cholesterol levels, the odds ratios (ORs) for incident metabolic syndrome after 5 years’ follow-up by quintiles of oxidized LDL were 2.1 for the second quintile, 2.4 for the third quintile, 2.8 for the fourth quintile and 3.5 for the fifth quintile. The adjusted ORs for incidence of dichotomous components of metabolic syndrome in the highest versus the lowest quintile of oxidized LDL were 2.1 for abdominal obesity, 2.4 for high fasting glucose, and 2.1 for high triglycerides. Higher concentration of oxidized LDL appears to be associated with increased incidence of metabolic syndrome overall, as well as its components of abdominal obesity, hyperglycaemia, and hypertriglyceridaemia.
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