Hyperuricaemia significantly associated with visceral fat accumulation and hypoadiponectinaemia in Japanese men
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This study was conducted to investigate the relationship between serum uric acid levels, visceral fat accumulation and serum adiponectin concentration in 1520 Japanese men having undergone annual health check-up both in 2004 and 2005. Visceral fat area (VFA) was estimated by a recently developed local (abdominal) bioelectrical impedance analysis and serum adiponectin concentration using a sandwich enzyme-linked immunosorbent assay (ELISA) system. Visceral fat accumulation was present in 56.1% of subjects presenting with hyperuricaemia, defined as 7 mg/dL (Japanese Society of Gout and Nucleic Acid Metabolism guidelines). Serum uric acid levels were positively associated with VFA, the one-year change in VFA being linked to the one-year change in serum uric acid levels. There was a negative correlation between serum uric acid levels and serum adiponectin concentration. Adiponectinaemia was a significant explanatory variable for serum uric acid levels in Japanese men, with hyperuricaemia significantly linked to visceral fat area and hypoadiponectinaemia.
Abstract
