Decrease in HDL cholesterol as a risk factor for deficit and decline in memory in midlife
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In order to examine the relationship between ATP-III categories of fasting serum lipids and short-term memory in middle-aged adults, short-term verbal memory was assessed using 20-word list in 3673 male and female participants of the Whitehall II study. Fully adjusted logistic regression analysis revealed that, compared to high HDL cholesterol, low HDL cholesterol was associated with greater odds of memory deficit (recall of ≤4 words) at the first and second wave of this study. Over the 5-year follow-up period, decrease in HDL cholesterol was associated with decline in memory (decrease of ≥2 words), with no interaction found for apolipoprotein E4 status. These results suggest that low HDL cholesterol is associated with poor memory and decline in memory in middle-aged adults.
Abstract
