Impaired fasting glucose as an excellent predictor of type 2 diabetes mellitus

This study had been designed to investigate whether metabolic syndrome predicts incident type 2 diabetes over 5 years. A total of 1844 subjects were recruited from the cohort study on the prevention of multiple metabolic disorders and metabolic syndrome in Jiangsu province, China, and followed-up for 5 years. Subjects presenting with metabolic syndrome (NCEP ATP III criteria) had a 2.3 adjusted relative risk (aRR) of developing type 2 diabetes compared to subjects without metabolic syndrome at baseline. The aRR for metabolic syndrome components was 5.4 for impaired fasting glucose (IFG), 2.6 for enlarged waist, 3.5 for elevated triglyceride, 4.7 for elevated blood pressure, and 2.4 for low HDL cholesterol. After further adjustments, only IFG was found to be statistically significant and there was no significant interaction between IFG and other metabolic syndrome components. In conclusion, the study results show that subjects with metabolic syndrome are at a higher risk of developing type 2 diabetes compared to those without metabolic syndrome. IFG was found to be an excellent predictor of type 2 diabetes with no significant interaction found between IFG and other metabolic syndrome components.

Abstract

Keywords:
Dyslipidaemia – Elevated blood pressure – HDL-cholesterol – Hypertriglyceridaemia – IFG – NCEP ATP III definition – Type 2 diabetes – Waist circumference