Significant correlation between adiponectin and fasting indices of insulin resistance in Greek children and adolescents
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The study aimed to measure serum adiponectin levels in Greek children and adolescents and to correlate them with body fat and insulin resistance. A total of 46 obese prepubertal children and 34 obese adolescents were compared with 43 matched control subjects. Serum adiponectin levels were significantly lower in obese participants than in nonobese participants, in obese children than in nonobese children, in obese adolescents than in nonobese adolescents, and in obese adolescent boys than in obese adolescent girls. Adiponectin significantly correlated with age, body mass index, body mass index standard deviation score, homeostasis model assessment (HOMA) for insulin resistance, and fasting glucose-to-insulin ratio. After adjusting for sex, adiponectin correlated with percent body fat. Moreover, among obese subjects, adiponectin significantly correlated with several indices of insulin resistance. Further investigation concerning the option of applying a simple measurement of serum adiponectin as biochemical screening tool in young obese subjects may be worthwhile.
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