Low high-density lipoprotein cholesterol levels in non-ST-segment elevation acute coronary syndromes
Document Actions
To determine the prevalence and prognostic significance of low HDL cholesterol (HDL-C) levels sampled on admission in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS), HDL-C levels were assessed among 93,263 NSTE ACS patients participating in the CRUSADE initiative from January 2001 through June 2006. In this patient population, 18.1% had very low HDL-C levels (10-29 mg/dL), 34.5% had low HDL-C levels (30-39 mg/dL), 38.5% had normal HDL-C levels (40-59 mg/dL), and 9% had high HDL-C levels (60-100 mg/dL). Compared to patients with normal and high HDL-C levels, those with very low HDL-C levels had the greatest risk for multivessel coronary disease on angiography and for in-hospital mortality. According to these results, almost one-fifth of NSTE ACS patients have very low in-hospital HDL-C levels, which add to a greater burden of atherosclerosis and a higher risk of mortality.
Abstract
