Strong association between metabolic syndrome and multiple organ damage in essential hypertension
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This study was conducted to estimate the prevalence of metabolic syndrome in hypertensive patients categorized according to the number of organ damage (OD) markers so as to assess the value of a systematic search for cardiac and extracardiac OD in metabolic syndrome patients. To this end, 3119 untreated and treated essential hypertensives participating in an observational registry of hypertension-related OD (ETODH) underwent extensive investigation for left ventricular hypertrophy (LVH) or LV concentric remodelling (cardiac OD), carotid plaques and/or intima-media thickening (vascular OD) and microalbuminuria and/or increased serum creatinine (renal OD). They were then classified as positive for none (group 0), one (group I), two (group II) or three markers (group III) of OD. The prevalence rates of metabolic syndrome progressively rose across groups, reaching a 2.3-fold increase in group III as compared to group 0. Among subjects with metabolic syndrome, 53% had two or three OD markers. In conclusion, there appears to be a strong association between metabolic syndrome and OD, indicating that a clustering of two or three OD markers is the prevalent cardiovascular phenotype in hypertensive patients presenting with metabolic syndrome.
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