Visceral fat accumulation and low plasma adiponectin levels as promoters of colorectal carcinogenesis
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There is accumulating epidemiological evidence that colorectal cancer (CRC) is associated with the metabolic syndrome and states of chronic hyperinsulinaemia and/or insulin resistance. As CRC is associated with a gradual loss of bodyweight, the association between obesity and CRC risk is difficult to evaluate. Aberrant crypt foci (ACF), thought to be a biomarker of CRC, can be classified as dysplastic ACF or non-dysplastic ACF by magnifying colonoscopy. Among the 94 participants enrolled in the study, 557 ACF including 67 dysplastic ACF (12%) were detected during colonoscopy. Multiple regression analysis revealed that the number of dysplastic ACF correlated with age and low plasma adiponectin levels, even after adjusting for confounding factors. In univariate correlation analysis, the number of dysplastic ACF significantly correlated with visceral fat area but not with subcutaneous fat area, and inversely correlated with plasma level of adiponectin. As visceral fat accumulation and a low plasma adiponectin level are associated with an established colorectal carcinogenesis biomarker, these obesity-related parameters may serve as novel targets for CRC prevention.
Abstract
