Excess BMI gained in infancy associated with risk of developing young adult-onset diabetes
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To examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes, Finnish national healthcare registers were used to identify subjects diagnosed with diabetes between 1992 and 1996 at 15-39 years of age. Nondiabetic control participants were chosen from the National Population Registry. The points of infancy maximum BMI and the BMI rebound figures were examined. Per 1.0 kg/m2 rise in infancy maximum BMI, the risk for type 1 diabetes significantly increased 1.19-fold, while per 1.0 kg/m2 rise in peak BMI at BMI rebound, the risk for type 2 diabetes significantly increased 1.77-fold. Higher values of BMI at these points corresponded to a larger BMI gain between birth and that developmental stage. In conclusion, (1) BMI gain in infancy among subjects who subsequently developed young adult-onset type 1 diabetes was faster than that of those who remained healthy, and (2) excess BMI gain in subjects who developed young-adult onset type 2 diabetes could already be seen during early childhood.
Abstract
