Specific components of metabolic syndrome increase the odds of metachronous neoplasia
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The association between colorectal cancer and obesity has been consistently reported in Western populations. The study was designed to investigate the relation between metachronous neoplasia and individual components of the metabolic syndrome (NCEP ATP III) in 2392 participants of two previous chemoprevention trials. Metabolic syndrome in women was associated with increased odds of metachronous neoplasia as were waist circumference in both genders and elevated fasting glucose in women, while none of the other components (i.e. hypertension, low HDL cholesterol and elevated triglyceride levels) were independently associated with metachronous neoplasia. When each trait was analyzed along quartiles, elevated glucose among women and large waist circumference among men were significantly associated with metachronous lesions. These results suggest that specific components of the metabolic syndrome, notably those that capture impaired glucose uptake (e.g. insulin resistance and/or compensatory hyperinsulinaemia), increase the odds of metachronous neoplasia.
Abstract
