Hyperglycaemia is associated with adverse lipid profile in Asians without prior history of diabetes

To investigate the associations of lipid profile with glucose levels, cross-sectional data of 10,374 men and 12,552 women from 14 cohorts representing seven Asian populations were included in the analysis. Multivariable adjusted regression analyses revealed that within each glucose category (normal, impaired fasting glucose and/or impaired glucose tolerance), fasting plasma glucose (FPG) levels were correlated with increasing levels of triglycerides, total cholesterol (TC), TC-to-high-density lipoprotein (HDL) ratio, and non-HDL cholesterol (non-HDL-C), and inversely associated with HDL-C in some but not all of the populations. Furthermore, the association of 2-h post-75-g oral glucose tolerance test plasma glucose (2hPG) to blood lipid levels showed a similar pattern, except that the inverse relationship between HDL-C and glucose was more frequently observed for 2hPG than for FPG among the different ethnic groups. In conclusion, in Asians without a history of diabetes, hyperglycaemia appears to be associated with adverse lipid profile, this association being more marked for 2hPG than for FPG.

Abstract

Keywords:
Cholesterol – Dyslipidaemia – HDL-C – Impaired glucose regulation – OGTT – Plasma glucose – Triglycerides