QRISK as an improved risk predictor compared to the established Anderson Framingham equation
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This prospective open cohort study aimed to evaluate the performance of the QRISK score for predicting 10-year risk of cardiovascular disease in nondiabetic subjects in an independent UK cohort of patients, and compare the QRISK performance with that of Framingham equations using external and independent validation. Of note is that the QRISK algorithm uses existing traditional risk factors, but also incorporates deprivation, family history, antihypertensive treatment, and body mass index. The QRISK algorithm was developed using a validated clinical research database (QRESEARCH) of routinely-collected data from general practitioner clinical computer systems. The independent validation of the QRISK score was based on a total of 1.07 million patients, registered between 1 January 1995 and 1 April 2006, with 43,990 cardiovascular events. The results indicate that compared to the Anderson Framingham equations, which, particularly in males, overpredict risk, the QRISK offers improved performance in predicting 10-year cardiovascular disease risk in a large cohort of UK patients. QRISK was found to underestimate 10-year cardiovascular disease risk, though the magnitude of the underprediction appeared to be smaller than the overprediction obtained with the Anderson Framingham equations. Of note is that a modified version (QRISK2) is being developed to incorporate ethnicity as input variable.
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