Visceral adipose tissue accumulation and markers of insulin resistance associated with early-stage colorectal neoplasia
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The aim of the study was to examine the relation of early-stage colorectal neoplasia to visceral fat area and markers of insulin resistance in Japanese subjects undergoing a comprehensive health screening. During a 3-year follow-up period, 108 cases of early-stage colorectal neoplasia, among which 22 early cancers, were detected among patients who received both colorectal cancer screening and abdominal computed tomography scanning. Conditional logistic regression analysis revealed that visceral fat area, but not subcutaneous fat area, was significantly and positively associated with colorectal cancer. Fasting glucose, a marker of insulin resistance in nondiabetic subjects, was also positively associated with colorectal risk. Contrarily, for colorectal adenomas, no associations were found. These findings suggest that visceral adipose accumulation and insulin resistance may promote the development of early-stage cancer but not adenoma in the colorectum.
Abstract
