March 2007
Volume 2, issue 3

The Metabolic Syndrome Institute Literature Watch features the latest articles on the metabolic syndrome. Click on the links below to view the abstracts for each article.

Adiponectin

Altinova AE, Toruner F, Bukan N, Yasar DG, Akturk M, Cakir N, Arslan M.
Decreased plasma adiponectin is associated with insulin resistance and HDL cholesterol in overweight subjects.
Endocr J. 2007 Jan 31; [Epub ahead of print]

Aragao CN, Souza LL, Cabanelas A, Oliveira KJ, Pazos-Moura CC.
Effect of experimental hypo- and hyperthyroidism on serum adiponectin.
Metabolism. 2007 Jan;56(1):6-11.

Bauche IB, El Mkadem SA, Pottier AM, Senou M, Many MC, Rezsohazy R, Penicaud L, Maeda N, Funahashi T, Brichard SM.
Overexpression of adiponectin targeted to adipose tissue in transgenic mice: impaired adipocyte differentiation.
Endocrinology. 2007 Jan 4; [Epub ahead of print]

Bobbert T, Wegewitz U, Brechtel L, Freudenberg M, Mai K, Mohlig M, Diederich S, Ristow M, Rochlitz H, Pfeiffer AF, Spranger J.
Adiponectin oligomers in human serum during acute and chronic exercise: relation to lipid metabolism and insulin sensitivity.
Int J Sports Med. 2007 Jan;28(1):1-8. Epub 2006 Nov 28.

Collins SC, Luan J, Thompson AJ, Daly A, Semple RK, O'rahilly S, Wareham NJ, Barroso I.
Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
Diabetologia. 2007 Mar;50(3):555-62. Epub 2007 Jan 10.

Gable DR, Matin J, Whittall R, Cakmak H, Li KW, Cooper J, Miller GJ, Humphries SE; on behalf of the HIFMECH investigators.
Common Adiponectin Gene Variants Show Different Effects on Risk of Cardiovascular Disease and Type 2 Diabetes in European Subjects.
Ann Hum Genet. 2007 Jan 11; [Epub ahead of print]

Han SH, Quon MJ, Kim JA, Koh KK.
Adiponectin and cardiovascular disease: response to therapeutic interventions.
J Am Coll Cardiol. 2007 Feb 6;49(5):531-8. Epub 2007 Jan 19.

Kanda T, Saegusa S, Takahashi T, Sumino H, Morimoto S, Nakahashi T, Iwai K, Matsumoto M.
Reduced-energy diet improves survival of obese KKAy mice with viral myocarditis: Induction of cardiac adiponectin expression.
Int J Cardiol. 2007 Jan 30; [Epub ahead of print]

Laughlin GA, Barrett-Connor E, May S, Langenberg C.
Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study.
Am J Epidemiol. 2007 Jan 15;165(2):164-74. Epub 2006 Nov 13.

Loos RJ, Ruchat S, Rankinen T, Tremblay A, Perusse L, Bouchard C.
Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study.
Am J Clin Nutr. 2007 Jan;85(1):26-34.

Neumeier M, Sigruener A, Eggenhofer E, Weigert J, Weiss TS, Schaeffler A, Schlitt HJ, Aslanidis C, Piso P, Langmann T, Schmitz G, Scholmerich J, Buechler C.
High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes.
Biochem Biophys Res Commun. 2007 Jan 12;352(2):543-8. Epub 2006 Nov 20.

Owecki M, Miczke A, Pupek-Musialik D, Bryl W, Cymerys M, Nikisch E, Sowinski J.
Circulating Serum Adiponectin Concentrations do not Differ between Obese and Non-obese Caucasians and are Unrelated to Insulin Sensitivity.
Horm Metab Res. 2007 Jan;39(1):25-30.

Polak J, Kovacova Z, Jacek M, Klimcakova E, Kovacikova M, Vitkova M, Kuda O, Sebela M, Samcova E, Stich V.
An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight premenopausal women.
Clin Sci (Lond). 2007 Jan 4; [Epub ahead of print]

Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, Ogawa Y.
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation.
Biochem Biophys Res Commun. 2007 Mar 2;354(1):45-9. Epub 2007 Jan 2.

Wannamethee SG, Tchernova J, Whincup P, Lowe GD, Rumley A, Brown K, Cherry L, Sattar N.
Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters.
Int J Obes (Lond). 2007 Jan 30; [Epub ahead of print]

Willemsen RH, van Dijk M, de Rijke YB, van Toorenenbergen AW, Mulder PG, Hokken-Koelega AC.
Effect of growth hormone therapy on serum adiponectin and resistin levels in short, small-for-gestational-age children and associations with cardiovascular risk parameters.
J Clin Endocrinol Metab. 2007 Jan;92(1):117-23. Epub 2006 Sep 26.

Zeng Q, Isobe K, Fu L, Ohkoshi N, Ohmori H, Takekoshi K, Kawakami Y.
Effects of exercise on adiponectin and adiponectin receptor levels in rats.
Life Sci. 2007 Jan 9;80(5):454-9. Epub 2006 Oct 5.

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Cardiovascular disease

Blanco-Colio LM, Martin-Ventura JL, de Teresa E, Farsang C, Gaw A, Gensini G, Leiter LA, Langer A, Martineau P, Hernandez G, Egido J; ACTFAST investigators.
Increased soluble Fas plasma levels in subjects at high cardiovascular risk: Atorvastatin on Inflammatory Markers (AIM) study, a substudy of ACTFAST.
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):168-74. Epub 2006 Oct 19.

Cabrera MA, Gebara OC, Diament J, Nussbacher A, Rosano G, Wajngarten M.
Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women.
Int J Cardiol. 2007 Jan 8;114(2):224-9. Epub 2006 Jun 19.

Caro JJ, O'brien JA, Hollenbeak CS, Spackman E, Ben-Joseph R, Okamoto LJ, Paramore LC.
Economic burden and risk of cardiovascular disease and diabetes in patients with different cardiometabolic risk profiles.
Value Health. 2007 Jan-Feb;10 Suppl 1:S12-20.

Ferreira AP, Oliveira CE, Franca NM.
Metabolic syndrome and risk factors for cardiovascular disease in obese children: the relationship with insulin resistance (HOMA-IR).
J Pediatr (Rio J). 2007 January/February;83(1):21-26. Epub 2006 Nov 28.

Han SH, Quon MJ, Kim JA, Koh KK.
Adiponectin and cardiovascular disease: response to therapeutic interventions.
J Am Coll Cardiol. 2007 Feb 6;49(5):531-8. Epub 2007 Jan 19.

Lee DS, Evans JC, Robins SJ, Wilson PW, Albano I, Fox CS, Wang TJ, Benjamin EJ, D'Agostino RB, Vasan RS.
Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33. Epub 2006 Nov 9.

Lorenzo C, Williams K, Hunt KJ, Haffner SM.
The National Cholesterol Education Program - Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes.
Diabetes Care. 2007 Jan;30(1):8-13.

McNicholas WT, Bonsignore MR; the Management Committee of EU COST ACTION B26.
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities.
Eur Respir J. 2007 Jan;29(1):156-78.

Meigs JB, Rutter MK, Sullivan LM, Fox CS, D'Agostino RB Sr, Wilson PW.
Impact of Insulin Resistance on Risk of Type 2 Diabetes and Cardiovascular Disease in People with Metabolic Syndrome.
Diabetes Care. 2007 Jan 26; [Epub ahead of print]

Moon JY, Park S, Rhee JH, Jee SH, Park CM, Choi DS, Park HY, Ko YG, Choi D, Jang Y, Chung N.
The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population.
Int J Cardiol. 2007 Jan 2;114(1):83-9. Epub 2006 May 8.

Targher G.
Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens.
Diabet Med. 2007 Jan;24(1):1-6.

Zhang X, Jia Y, Jackson EK, Tofovic SP.
2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats.
J Cardiovasc Pharmacol. 2007 Jan;49(1):56-63.

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Diabetes

Chiu HK, Tsai EC, Juneja R, Stoever J, Brooks-Worrell B, Goel A, Palmer JP.
Equivalent insulin resistance in latent autoimmune diabetes in adults (LADA) and type 2 diabetic patients.
Diabetes Res Clin Pract. 2007 Jan 16; [Epub ahead of print]

Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y.
Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.
Diabetes. 2007 Jan;56(1):24-33.

Keating GM, Croom KF.
Fenofibrate: a review of its use in primary dyslipidaemia, the metabolic syndrome and type 2 diabetes mellitus.
Drugs. 2007;67(1):121-53.

Lorenzo C, Williams K, Hunt KJ, Haffner SM.
The National Cholesterol Education Program - Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes.
Diabetes Care. 2007 Jan;30(1):8-13.

Meigs JB, Rutter MK, Sullivan LM, Fox CS, D'Agostino RB Sr, Wilson PW.
Impact of Insulin Resistance on Risk of Type 2 Diabetes and Cardiovascular Disease in People with Metabolic Syndrome.
Diabetes Care. 2007 Jan 26; [Epub ahead of print]

Yuen KC, Dunger DB.
Therapeutic aspects of growth hormone and insulin-like growth factor-I treatment on visceral fat and insulin sensitivity in adults.
Diabetes Obes Metab. 2007 Jan;9(1):11-22.

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Diet, Nutrition and Metabolism

Ardiansyah, Shirakawa H, Koseki T, Hashizume K, Komai M.
The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid.
Br J Nutr. 2007 Jan;97(1):67-76.

Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Horkko S, Steinberg D, Palinski W, Witztum JL, Li AC.
A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome.
Arterioscler Thromb Vasc Biol. 2007 Jan 25; [Epub ahead of print]

Mendoza JA, Drewnowski A, Christakis DA.
Dietary Energy Density is Associated with Obesity and the Metabolic Syndrome in US Adults.
Diabetes Care. 2007 Jan 17; [Epub ahead of print]

Nicolson GL.
Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function.
J Cell Biochem. 2007 Jan 22; [Epub ahead of print]

Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, Ogawa Y.
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation.
Biochem Biophys Res Commun. 2007 Mar 2;354(1):45-9. Epub 2007 Jan 2.

Takemoto T, Nishio Y, Sekine O, Ikeuchi C, Nagai Y, Maeno Y, Maegawa H, Kimura H, Kashiwagi A.
RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.
FEBS Lett. 2007 Jan 23;581(2):218-22. Epub 2006 Dec 14.

Sanchez-Lozada LG, Tapia E, Jimenez A, Bautista P, Cristobal M, Nepomuceno T, Soto V, Avila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J, Franco M.
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.
Am J Physiol Renal Physiol. 2007 Jan;292(1):F423-9. Epub 2006 Aug 29.

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Drug Therapy

Athyros VG, Mikhailidis DP, Liberopoulos EN, Kakafika AI, Karagiannis A, Papageorgiou AA, Tziomalos K, Ganotakis ES, Elisaf M.
Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: A subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study.
Nephrol Dial Transplant. 2007 Jan;22(1):118-127. Epub 2006 Sep 23.

Blanco-Colio LM, Martin-Ventura JL, de Teresa E, Farsang C, Gaw A, Gensini G, Leiter LA, Langer A, Martineau P, Hernandez G, Egido J; ACTFAST investigators.
Increased soluble Fas plasma levels in subjects at high cardiovascular risk: Atorvastatin on Inflammatory Markers (AIM) study, a substudy of ACTFAST.
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):168-74. Epub 2006 Oct 19.

Boden WE, O'rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk W, Knudtson M, Dada M, Casperson P, Harris CL, Spertus JA, Shaw L, Chaitman BR, Mancini GB, Berman DS, Gau G, Weintraub WS; COURAGE Trial Co-Principal Investigators and Study Coordinators.
The Evolving Pattern of Symptomatic Coronary Artery Disease in the United States and Canada: Baseline Characteristics of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) Trial.
Am J Cardiol. 2007 Jan 15;99(2):208-12. Epub 2006 Nov 17.

Goethe JW, Szarek BL, Caley CF, Woolley SB.
Signs and symptoms associated with the metabolic syndrome in psychiatric inpatients receiving antipsychotics: a retrospective chart review.
J Clin Psychiatry. 2007 Jan;68(1):22-8.

Hanefeld M, Marx N, Pfutzner A, Baurecht W, Lubben G, Karagiannis E, Stier U, Forst T.
Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: the PIOSTAT Study.
J Am Coll Cardiol. 2007 Jan 23;49(3):290-7. Epub 2007 Jan 8.

Kraemer de Aguiar LG, Laflor CM, Bahia L, Villela NR, Wiernsperger N, Bottino DA, Bouskela E.
Metformin improves skin capillary reactivity in normoglycaemic subjects with the metabolic syndrome.
Diabet Med. 2007 Jan 29; [Epub ahead of print]

Kralisch S, Bluher M, Paschke R, Stumvoll M, Fasshauer M.
Adipokines and adipocyte targets in the future management of obesity and the metabolic syndrome.
Mini Rev Med Chem. 2007 Jan;7(1):39-45.

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Epidemiology

Bal K, Oder M, Sahin AS, Karatas CT, Demir O, Can E, Gumus BH, Ozer K, Sahin OG, Esen AA.
Prevalence of Metabolic Syndrome and Its Association with Erectile Dysfunction Among Urologic Patients: Metabolic Backgrounds of Erectile Dysfunction.
Urology. 2007 Jan 30; [Epub ahead of print]

Beebe-Dimmer JL, Dunn RL, Sarma AV, Montie JE, Cooney KA.
Features of the metabolic syndrome and prostate cancer in African-American men.
Cancer. 2007 Jan 30; [Epub ahead of print]

Cabrera MA, Gebara OC, Diament J, Nussbacher A, Rosano G, Wajngarten M.
Metabolic syndrome, abdominal obesity, and cardiovascular risk in elderly women.
Int J Cardiol. 2007 Jan 8;114(2):224-9. Epub 2006 Jun 19.

Fu JF, Liang L, Zou CC, Hong F, Wang CL, Wang XM, Zhao ZY.
Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention.
Int J Obes (Lond). 2007 Jan;31(1):15-22. Epub 2006 Sep 5.

Gentles D, Metcalf P, Dyall L, Sundborn G, Schaaf D, Black P, Scragg R, Jackson R.
Metabolic syndrome prevalence in a multicultural population in Auckland, New Zealand.
N Z Med J. 2007 Jan 26;120(1248):U2399.

Ghosh A.
Factor analysis of risk variables associated with metabolic syndrome in Asian Indian adolescents.
Am J Hum Biol. 2007 Jan-Feb;19(1):34-40.

Hadaegh F, Zabetian A, Harati H, Azizi F.
Metabolic syndrome in normal-weight Iranian adults.
Ann Saudi Med. 2007 Jan-Feb;27(1):18-24.

Hayashi T, Boyko EJ, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY.
Minimum waist and visceral fat values for identifying Japanese Americans at risk for the metabolic syndrome.
Diabetes Care. 2007 Jan;30(1):120-7.

Ishikawa S, Kayaba K, Gotoh T, Nakamura Y, Kajii E.
Metabolic syndrome and C-reactive protein in the general population: JMS Cohort Study.
Circ J. 2007 Jan;71(1):26-31.

Karvounaris SA, Sidiropoulos PI, Papadakis JA, Spanakis EK, Bertsias GK, Kritikos HD, Ganotakis ES, Boumpas DT.
Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates with disease activity: a retrospective, cross-sectional, controlled, study.
Ann Rheum Dis. 2007 Jan;66(1):28-33. Epub 2006 Jun 22.

Kim HM, Park J, Kim HS, Kim DH.
Prevalence of the metabolic syndrome in Korean adolescents aged 12-19 years from the Korean National Health and Nutrition Examination Survey 1998 and 2001.
Diabetes Res Clin Pract. 2007 Jan;75(1):111-4. Epub 2006 Jun 5.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala EL, Haapala I, Nissinen A, Rauramaa R.
Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women.
Dement Geriatr Cogn Disord. 2007;23(1):29-34. Epub 2006 Oct 27.

Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, Kim DY, Kwon HS, Kim SR, Lee CB, Oh SJ, Park CY, Yoo HJ.
Appropriate waist circumference cutoff points for central obesity in Korean adults.
Diabetes Res Clin Pract. 2007 Jan;75(1):72-80. Epub 2006 Jun 2.

Leite ML, Nicolosi A, Firmo JO, Lima-Costa MF.
Features of metabolic syndrome in non-diabetic Italians and Brazilians: a discriminant analysis.
Int J Clin Pract. 2007 Jan;61(1):32-8.

Lin SX, Pi-Sunyer EX.
Prevalence of the metabolic syndrome among US middle-aged and older adults with and without diabetes--a preliminary analysis of the NHANES 1999-2002 data.
Ethn Dis. 2007 Winter;17(1):35-9.

Loucks EB, Rehkopf DH, Thurston RC, Kawachi I.
Socioeconomic disparities in metabolic syndrome differ by gender: evidence from NHANES III.
Ann Epidemiol. 2007 Jan;17(1):19-26. Epub 2006 Nov 29.

Mancia G, Bombelli M, Corrao G, Facchetti R, Madotto F, Giannattasio C, Trevano FQ, Grassi G, Zanchetti A, Sega R.
Metabolic syndrome in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study: daily life blood pressure, cardiac damage, and prognosis.
Hypertension. 2007 Jan;49(1):40-7. Epub 2006 Nov 27.

Mondy K, Turner Overton E, Grubb J, Tong S, Seyfried W, Powderly W, Yarasheski K.
Metabolic Syndrome in HIV-Infected Patients from an Urban, Midwestern US Outpatient Population.
Clin Infect Dis. 2007 Mar 1;44(5):726-34. Epub 2007 Jan 22.

Moon JY, Park S, Rhee JH, Jee SH, Park CM, Choi DS, Park HY, Ko YG, Choi D, Jang Y, Chung N.
The applicability of the Asian modified criteria of the metabolic syndrome in the Korean population.
Int J Cardiol. 2007 Jan 2;114(1):83-9. Epub 2006 May 8.

Perichart-Perera O, Balas-Nakash M, Schiffman-Selechnik E, Barbato-Dosal A, Vadillo-Ortega F.
Obesity increases metabolic syndrome risk factors in school-aged children from an urban school in Mexico city.
J Am Diet Assoc. 2007 Jan;107(1):81-91.

Skoumas J, Papadimitriou L, Pitsavos C, Masoura C, Giotsas N, Chrysohoou C, Toutouza M, Panagiotakos D, Stefanadis C.
Metabolic syndrome prevalence and characteristics in Greek adults with familial combined hyperlipidemia.
Metabolism. 2007 Jan;56(1):135-41.

Young DO, Lund RJ, Haynatzki G, Dunlay RW.
Prevalence of the metabolic syndrome in an incident dialysis population.
Hemodial Int. 2007 Jan;11(1):86-95.

Zabetian A, Hadaegh F, Azizi F.
Prevalence of metabolic syndrome in Iranian adult population, concordance between the IDF with the ATPIII and the WHO definitions.
Diabetes Res Clin Pract. 2007 Jan 15; [Epub ahead of print]

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Exercise & Physical Activity

Freson K, Stolarz K, Aerts R, Brand E, Brand-Herrmann SM, Kawecka-Jaszcz K, Kuznetsova T, Tikhonoff V, Thijs L, Vermylen J, Staessen JA, Van Geet C; European Project on Genes in Hypertension Investigators.
-391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies.
J Hypertens. 2007 Jan;25(1):117-25.

Miyatake N, Saito T, Wada J, Miyachi M, Tabata I, Matsumoto S, Nishikawa H, Makino H, Numata T.
Comparison of ventilatory threshold and exercise habits between Japanese men with and without metabolic syndrome.
Diabetes Res Clin Pract. 2007 Jan 3; [Epub ahead of print]

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Genetics

Abdollahi MR, Lewis RM, Gaunt TR, Cumming DV, Rodriguez S, Rose-Zerilli M, Collins AR, Syddall HE, Howell WM, Cooper C, Godfrey KM, Cameron IT, Day IN.
Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits.
Hum Mutat. 2007 Jan 8; [Epub ahead of print]

Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL.
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.
Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E298-307. Epub 2006 Sep 19.

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Hypertension

Abdilla N, Tormo MC, Fabia MJ, Chaves FJ, Saez G, Redon J.
Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension.
J Hum Hypertens. 2007 Jan;21(1):68-75. Epub 2006 Oct 26.

Kidambi S, Kotchen JM, Grim CE, Raff H, Mao J, Singh RJ, Kotchen TA.
Association of Adrenal Steroids With Hypertension and the Metabolic Syndrome in Blacks.
Hypertension. 2007 Jan 15; [Epub ahead of print]

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Insulin Sensitivity / Insulin Resistance

Li C, Ford ES, McGuire LC, Mokdad AH.
Association of metabolic syndrome and insulin resistance with congestive heart failure: findings from the Third National Health and Nutrition Examination Survey.
J Epidemiol Community Health. 2007 Jan;61(1):67-73.

Meigs JB, Rutter MK, Sullivan LM, Fox CS, D'Agostino RB Sr, Wilson PW.
Impact of Insulin Resistance on Risk of Type 2 Diabetes and Cardiovascular Disease in People with Metabolic Syndrome.
Diabetes Care. 2007 Jan 26; [Epub ahead of print]

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Lipoproteins

Rizzo M, Berneis K.
Small, dense low-density-lipoproteins and the metabolic syndrome.
Diabetes Metab Res Rev. 2007 Jan;23(1):14-20.

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Nitric Oxide

Gonzalez-Sanchez JL, Martinez-Larrad MT, Saez ME, Zabena C, Martinez-Calatrava MJ, Serrano-Rios M.
Endothelial nitric oxide synthase haplotypes are associated with features of metabolic syndrome.
Clin Chem. 2007 Jan;53(1):91-7. Epub 2006 Nov 16.

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Non-Alcoholic Fatty Liver Disease

Angelico F, Burattin M, Alessandri C, Del Ben M, Lirussi F.
Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis.
Cochrane Database Syst Rev. 2007 Jan 24;(1):CD005166.

Toshimitsu K, Matsuura B, Ohkubo I, Niiya T, Furukawa S, Hiasa Y, Kawamura M, Ebihara K, Onji M.
Dietary habits and nutrient intake in non-alcoholic steatohepatitis.
Nutrition. 2007 Jan;23(1):46-52. Epub 2006 Nov 29.

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Obesity

De Lorenzo A, Del Gobbo V, Premrov MG, Bigioni M, Galvano F, Di Renzo L.
Normal-weight obese syndrome: early inflammation?
Am J Clin Nutr. 2007 Jan;85(1):40-5.

Khoo CM, Liew CF, Chew SK, Tai ES.
The impact of central obesity as a prerequisite for the diagnosis of metabolic syndrome.
Obesity (Silver Spring). 2007 Jan;15(1):262-9.

Laclaustra M, Corella D, Ordovas JM.
Metabolic syndrome pathophysiology: The role of adipose tissue.
Nutr Metab Cardiovasc Dis. 2007 Jan 29; [Epub ahead of print]

Mule G, Nardi E, Cottone S, Cusimano P, Incalcaterra F, Ester Giandalia M, Palermo A, Mezzatesta G, Cerasola G.
Impact of metabolic syndrome on left ventricular mass in overweight and obese hypertensive subjects.
Int J Cardiol. 2007 Jan 26; [Epub ahead of print]

Rasouli N, Molavi B, Elbein SC, Kern PA.
Ectopic fat accumulation and metabolic syndrome.
Diabetes Obes Metab. 2007 Jan;9(1):1-10.

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PCOS / Menopause / Metabolic Syndrome in Women

Corton M, Botella-Carretero JI, Benguria A, Villuendas G, Zaballos A, San Millan JL, Escobar-Morreale HF, Peral B.
Differential gene expression profile in omental adipose tissue in women with polycystic ovary syndrome.
J Clin Endocrinol Metab. 2007 Jan;92(1):328-37. Epub 2006 Oct 24.

Loevinger BL, Muller D, Alonso C, Coe CL.
Metabolic syndrome in women with chronic pain.
Metabolism. 2007 Jan;56(1):87-93.

Maggio M, Lauretani F, Ceda GP, Bandinelli S, Basaria S, Paolisso G, Ble A, Egan JM, Metter EJ, Abbatecola AM, Zuliani G, Ruggiero C, Valenti G, Guralnik JM, Ferrucci L.
Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study.
Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E353-8. Epub 2006 Sep 12.

Mavri A, Bastelica D, Poggi M, Morange P, Peiretti F, Verdier M, Juhan-Vague I, Alessi MC.
Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women.
Thromb Haemost. 2007 Jan;97(1):62-6

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Pediatrics

Akinci G, Coskun S, Akinci B, Hekimsoy Z, Bayindir P, Onur E, Ozmen B.
Atherosclerosis risk factors in children of parents with the metabolic syndrome.
Atherosclerosis. 2007 Jan 6; [Epub ahead of print]

Ekelund U, Ong KK, Linne Y, Neovius M, Brage S, Dunger DB, Wareham NJ, Rossner S.
Association of weight gain in infancy and early childhood with metabolic risk in young adults.
J Clin Endocrinol Metab. 2007 Jan;92(1):98-103. Epub 2006 Oct 10.

Ferreira AP, Oliveira CE, Franca NM.
Metabolic syndrome and risk factors for cardiovascular disease in obese children: the relationship with insulin resistance (HOMA-IR).
J Pediatr (Rio J). 2007 January/February;83(1):21-26. Epub 2006 Nov 28.

van Dijk M, Bannink EM, van Pareren YK, Mulder PG, Hokken-Koelega AC.
Risk factors for diabetes mellitus type 2 and metabolic syndrome are comparable for previously growth hormone-treated young adults born small for gestational age (sga) and untreated short SGA controls.
J Clin Endocrinol Metab. 2007 Jan;92(1):160-5. Epub 2006 Oct 24.

Veena SR, Geetha S, Leary SD, Saperia J, Fisher DJ, Kumaran K, Coakley P, Stein CE, Fall CH.
Relationships of maternal and paternal birthweights to features of the metabolic syndrome in adult offspring: an inter-generational study in South India.
Diabetologia. 2007 Jan;50(1):43-54. Epub 2006 Dec 2.

Weghuber D, Zaknun D, Nasel C, Willforth-Ehringer A, Muller T, Boriss-Riedl M, Widhalm K.
Early cerebrovascular disease in a 2-year-old with extreme obesity and complete metabolic syndrome due to feeding of excessively high amounts of energy.
Eur J Pediatr. 2007 Jan;166(1):37-41. Epub 2006 Aug 22.

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Risk Factors

Chen SY, Chen CL, Shen ML.
Manifestations of metabolic syndrome associated with male gout in different age strata.
Clin Rheumatol. 2007 Jan 26; [Epub ahead of print]

Choi HK, Ford ES, Li C, Curhan G.
Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey.
Arthritis Rheum. 2007 Jan 31;57(1):109-115 [Epub ahead of print]

Chung CP, Oeser A, Solus JF, Avalos I, Gebretsadik T, Shintani A, Raggi P, Sokka T, Pincus T, Stein CM.
Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis.
Atherosclerosis. 2007 Jan 29; [Epub ahead of print]

Correll CU, Frederickson AM, Kane JM, Manu P.
Does antipsychotic polypharmacy increase the risk for metabolic syndrome?
Schizophr Res. 2007 Jan;89(1-3):91-100. Epub 2006 Oct 27.

Coughlin SR, Mawdsley L, Mugarza JA, Wilding JP, Calverley PM.
Cardiovascular and metabolic effects of CPAP in obese men with OSA.
Eur Respir J. 2007 Jan 24; [Epub ahead of print]

Coutinho Tde A, Turner ST, Peyser PA, Bielak LF, Sheedy PF 2nd, Kullo IJ.
Associations of serum uric Acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis.
Am J Hypertens. 2007 Jan;20(1):83-9.

Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, Montori VM.
Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies.
J Am Coll Cardiol. 2007 Jan 30;49(4):403-14. Epub 2007 Jan 12.

Garcia RG, Perez M, Maas R, Schwedhelm E, Boger RH, Lopez-Jaramillo P.
Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.
Int J Cardiol. 2007 Jan 15; [Epub ahead of print]

Golledge J, Leicht A, Crowther RG, Clancy P, Spinks WL, Quigley F.
Association of obesity and metabolic syndrome with the severity and outcome of intermittent claudication.
J Vasc Surg. 2007 Jan;45(1):40-6. Epub 2006 Nov 21.

Kahraman G, Sahin T, Kilic T, Baytugan NZ, Agacdiken A, Ural E, Ural D, Komsuoglu B.
The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome.
Int J Cardiol. 2007 Feb 14;115(3):391-6. Epub 2007 Jan 9.

Nunes JP.
The risk factor association syndrome as a barisystemic syndrome: A view on obesity and the metabolic syndrome.
Med Hypotheses. 2007;68(3):541-5. Epub 2006 Oct 9.

Ozden C, Ozdal OL, Urgancioglu G, Koyuncu H, Gokkaya S, Memis A.
The correlation between metabolic syndrome and prostatic growth in patients with benign prostatic hyperplasia.
Eur Urol. 2007 Jan;51(1):199-203; discussion 204-6. Epub 2006 Jun 14.

Razay G, Vreugdenhil A, Wilcock G.
The metabolic syndrome and Alzheimer disease.
Arch Neurol. 2007 Jan;64(1):93-6.

Santos AC, Ebrahim S, Barros H.
Alcohol intake, smoking, sleeping hours, physical activity and the metabolic syndrome.
Prev Med. 2007 Jan 16; [Epub ahead of print]

Soto Gonzalez A, Bellido D, Buno MM, Pertega S, De Luis D, Martinez-Olmos M, Vidal O.
Predictors of the metabolic syndrome and correlation with computed axial tomography.
Nutrition. 2007 Jan;23(1):36-45.

Wassink AM, Olijhoek JK, Visseren FL.
The metabolic syndrome: metabolic changes with vascular consequences.
Eur J Clin Invest. 2007 Jan;37(1):8-17.

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Coordinated by Dr. Scott Grundy, President of the IAS