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The Metabolic Syndrome Institute Literature Watch features the latest articles on the metabolic syndrome. Click on the links below to view the abstracts for each article.
Adipokines
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Is PBEF/Visfatin/Nampt an authentic adipokine relevant to the metabolic syndrome?
Sethi JK.
Curr Hypertens Rep. 2007 Mar;9(1):33-38.
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Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: nonalcoholic fatty liver disease.
Baranova A, Randhawa M, Jarrar M, Younossi ZM.
Expert Rev Mol Diagn. 2007 Mar;7(2):195-205.
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Adipose Tissue Disorders
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Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome.
Iacobellis G, Sharma AM, Pellicelli AM, Grisorio B, Barbarini G, Barbaro G.
Curr HIV Res. 2007 Mar;5(2):275-9.
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Predictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based study.
Onat A, Sari I, Hergenc G, Yazici M, Uyarel H, Can G, Sansoy V.
Metabolism. 2007 Mar;56(3):348-56.
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Relationship between C-reactive protein and atherosclerotic risk factors and oxidative stress markers among young persons 10-18 years old.
Kelishadi R, Sharifi M, Khosravi A, Adeli K.
Clin Chem. 2007 Mar;53(3):456-64. Epub 2007 Jan 26.
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Cardiovascular Disease
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LRP6 mutation in a family with early coronary disease and metabolic risk factors.
Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP.
Science. 2007 Mar 2;315(5816):1278-82.
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Lack of synergistic effects of metabolic syndrome and plasma fibrinogen on coronary events and mortality in moderate CKD.
Ramkumar N, Murtaugh MA, Cheung AK, Beddhu S.
Am J Kidney Dis. 2007 Mar;49(3):356-64.
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Metabolic syndrome in HIV-infected patients from an urban, midwestern US outpatient population.
Mondy K, Overton ET, Grubb J, Tong S, Seyfried W, Powderly W, Yarasheski K.
Clin Infect Dis. 2007 Mar 1;44(5):726-34. Epub 2007 Jan 22.
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Metabolic syndrome-related conditions among people with and without gout: prevalence and resource use.
Novak S, Melkonian AK, Patel PA, Kleinman NL, Joseph-Ridge N, Brook RA.
Curr Med Res Opin. 2007 Mar;23(3):623-30.
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Is height associated with cardiovascular risk in Chinese adults?
Schooling CM, Thomas GN, Leung GM, Ho SY, Janus ED, Lam TH.
Epidemiology. 2007 Mar;18(2):274-8.
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Excessive sympathetic activation in heart failure with obesity and metabolic syndrome: characteristics and mechanisms.
Grassi G, Seravalle G, Quarti-Trevano F, Scopelliti F, Dell'Oro R, Bolla G, Mancia G.
Hypertension. 2007 Mar;49(3):535-41. Epub 2007 Jan 8.
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Association of adrenal steroids with hypertension and the metabolic syndrome in blacks.
Kidambi S, Kotchen JM, Grim CE, Raff H, Mao J, Singh RJ, Kotchen TA.
Hypertension. 2007 Mar;49(3):704-11. Epub 2006 Dec 11. Erratum in: Hypertension. 2007 Mar;49(3):e20.
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The metabolic syndrome and the carotid artery structure in noninstitutionalized elderly subjects: the three-city study.
Empana JP, Zureik M, Gariepy J, Courbon D, Dartigues JF, Ritchie K, Tzourio C, Alperovitch A, Ducimetiere P.
Stroke. 2007 Mar;38(3):893-9. Epub 2007 Feb 1.
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Diabetes
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Multiple risk factors for cardiovascular disease and diabetes mellitus.
Smith SC Jr.
Am J Med. 2007 Mar;120(3 Suppl 1):S3-S11. Review.
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A cascade of events -- obesity, metabolic syndrome, and type 2 diabetes mellitus in youth.
McGillis Bindler RC.
Nurs Clin North Am. 2007 Mar;42(1):29-42, vi. Review.
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Diet, Nutrition and Metabolism
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Milk and the metabolic syndrome.
Pfeuffer M, Schrezenmeir J.
Obes Rev. 2007 Mar;8(2):109-18. Review.
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Effects of low- and high-volume resistance exercise on postprandial lipaemia.
Zafeiridis A, Goloi E, Petridou A, Dipla K, Mougios V, Kellis S.
Br J Nutr. 2007 Mar;97(3):471-7.
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Drug Therapy
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Therapeutic options for modifying cardiometabolic risk factors.
Aronne LJ.
Am J Med. 2007 Mar;120(3 Suppl 1):S26-34. Review.
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Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome.
Pershadsingh HA.
Expert Opin Investig Drugs. 2007 Mar;16(3):291-302. Review.
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Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level.
Hiuge A, Tenenbaum A, Maeda N, Benderly M, Kumada M, Fisman EZ, Tanne D, Matas Z, Hibuse T, Fujita K, Nishizawa H, Adler Y, Motro M, Kihara S, Shimomura I, Behar S, Funahashi T.
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):635-41. Epub 2006 Dec 28.
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Epidemiology
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Prevalence of undiagnosed metabolic syndrome in a population of adult asymptomatic subjects.
Bo S, Ciccone G, Pearce N, Merletti F, Gentile L, Cassader M, Pagano G.
Diabetes Res Clin Pract. 2007 Mar;75(3):362-5. Epub 2006 Aug 22.
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Population-based family case-control proband study on familial aggregation of metabolic syndrome: finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5).
Chiu YH, Lin WY, Wang PE, Chen YD, Wang TT, Warwick J, Chen TH.
Diabetes Res Clin Pract. 2007 Mar;75(3):348-56. Epub 2006 Aug 28.
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The metabolic syndrome and the carotid artery structure in noninstitutionalized elderly subjects: the three-city study.
Empana JP, Zureik M, Gariepy J, Courbon D, Dartigues JF, Ritchie K, Tzourio C, Alperovitch A, Ducimetiere P.
Stroke. 2007 Mar;38(3):893-9. Epub 2007 Feb 1.
View
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Association of adrenal steroids with hypertension and the metabolic syndrome in blacks.
Kidambi S, Kotchen JM, Grim CE, Raff H, Mao J, Singh RJ, Kotchen TA.
Hypertension. 2007 Mar;49(3):704-11. Epub 2006 Dec 11. Erratum in: Hypertension. 2007 Mar;49(3):e20.
View
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Metabolic syndrome in HIV-infected patients from an urban, midwestern US outpatient population.
Mondy K, Overton ET, Grubb J, Tong S, Seyfried W, Powderly W, Yarasheski K.
Clin Infect Dis. 2007 Mar 1;44(5):726-34. Epub 2007 Jan 22.
View
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Metabolic syndrome-related conditions among people with and without gout: prevalence and resource use.
Novak S, Melkonian AK, Patel PA, Kleinman NL, Joseph-Ridge N, Brook RA.
Curr Med Res Opin. 2007 Mar;23(3):623-30.
View
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Apolipoprotein B is associated with metabolic syndrome in Chinese families with familial combined hyperlipidemia, familial hypertriglyceridemia and familial hypercholesterolemia.
Pei WD, Sun YH, Lu B, Liu Q, Zhang CY, Zhang J, Jia YH, Lu ZL, Hui RT, Liu LS, Yang YJ.
Int J Cardiol. 2007 Mar 20;116(2):194-200. Epub 2006 Jul 10.
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Hepatitis C, metabolic syndrome, and inflammatory markers: results from the Third National Health and Nutrition Examination Survey [NHANES III].
Shaheen M, Echeverry D, Oblad MG, Montoya MI, Teklehaimanot S, Akhtar AJ.
Diabetes Res Clin Pract. 2007 Mar;75(3):320-6. Epub 2006 Aug 17.
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Pongchaiyakul C, Nguyen TV, Wanothayaroj E, Karusan N, Klungboonkrong V.
Prevalence of metabolic syndrome and its relationship to weight in the Thai population.
J Med Assoc Thai. 2007 Mar;90(3):459-67.
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Exercise & Physical Activity
Genetics
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Population-based family case-control proband study on familial aggregation of metabolic syndrome: finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5).
Chiu YH, Lin WY, Wang PE, Chen YD, Wang TT, Warwick J, Chen TH.Diabetes Res Clin Pract. 2007 Mar;75(3):348-56. Epub 2006 Aug 28.
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Hypertension
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Therapeutic interventions for hypertension in metabolic syndrome: a comprehensive approach.
Ganne S, Arora S, Karam J, McFarlane SI.
Expert Rev Cardiovasc Ther. 2007 Mar;5(2):201-11. Review.
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Association of adrenal steroids with hypertension and the metabolic syndrome in blacks.
Kidambi S, Kotchen JM, Grim CE, Raff H, Mao J, Singh RJ, Kotchen TA.
Hypertension. 2007 Mar;49(3):704-11. Epub 2006 Dec 11. Erratum in: Hypertension. 2007 Mar;49(3):e20.
View
Insulin Sensitivity / Insulin Resistance
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Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle.
Ye J.
Endocr Metab Immune Disord Drug Targets. 2007 Mar;7(1):65-74. Review.
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Non-Alcoholic Fatty Liver Disease
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Post-load insulin resistance is an independent predictor of hepatic fibrosis in Virus C Chronic Hepatitis and in Nonalcoholic Fatty Liver Disease.
Svegliati-Baroni G, Bugianesi E, Bousheral T, Ridolfi F, Marini F, Tarsetti F, Ancarani F, Petrelli E, Peruzzi E, Lo Cascio M, Rizzetto M, Marchesini G, Benedetti A.
Gut. 2007 Mar 28; [Epub ahead of print]
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Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: Evidence from a case-control study.
Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, Vanni E, Fargion S.
Am J Gastroenterol. 2007 Mar 27; [Epub ahead of print]
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Fatty liver and the metabolic syndrome.
Neuschwander-Tetri BA.
Curr Opin Gastroenterol. 2007 Mar;23(2):193-8. Review.
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Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: nonalcoholic fatty liver disease.
Baranova A, Randhawa M, Jarrar M, Younossi ZM.
Expert Rev Mol Diagn. 2007 Mar;7(2):195-205.
View
Obesity
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Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the co-morbidities of obesity.
Harman-Boehm I, Bluher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E, Shai I, Kloting N, Stumvoll M, Bashan N, Rudich A.
J Clin Endocrinol Metab. 2007 Mar 20; [Epub ahead of print]
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The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis.
Rojas-Rodriguez J, Escobar-Linares LE, Garcia-Carrasco M, Escarcega RO, Fuentes-Alexandro S, Zamora-Ustaran A.
Med Hypotheses. 2007 Mar 16; [Epub ahead of print]
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Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-99.
Kadota A, Hozawa A, Okamura T, Kadowaki T, Nakmaura K, Murakami Y, Hayakawa T, Kita Y, Okayama A, Nakamura Y, Kashiwagi A, Ueshima H.
Diabetes Care. 2007 Mar 15; [Epub ahead of print]
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Impact of weight change on albuminuria in the general population.
Bello AK, de Zeeuw D, Nahas ME, Brantsma AH, Bakker SJ, de Jong PE, Gansevoort RT.
Nephrol Dial Transplant. 2007 Mar 14; [Epub ahead of print]
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Impact of weight loss on the metabolic syndrome.
Phelan S, Wadden TA, Berkowitz RI, Sarwer DB, Womble LG, Cato RK, Rothman R.
Int J Obes (Lond). 2007 Mar 13; [Epub ahead of print]
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Corporeal weight gain and metabolic syndrome in living kidney donors after nephrectomy.
Ferreira-Filho SR, da Silva Passos L, Ribeiro MB.
Transplant Proc. 2007 Mar;39(2):403-6.
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PCOS / Menopause / Metabolic Syndrome in Women
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Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome.
Chen MJ, Yang WS, Yang JH, Chen CL, Ho HN, Yang YS.
Hypertension. 2007 Mar 26; [Epub ahead of print]
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alpha(2beta) adrenoreceptor 301-303 deletion polymorphism in polycystic ovary syndrome.
Saltamavros AD, Adonakis G, Kritikou S, Koika V, Koufogiannis K, Spyropoulos K, Kourounis G, Flordellis C, Kyriazopoulou V, Georgopoulos NA.
Clin Auton Res. 2007 Mar 16; [Epub ahead of print]
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Clinical and metabolic features of polycystic ovary syndrome.
Li L, Yang D, Chen X, Chen Y, Feng S, Wang L.
Int J Gynaecol Obstet. 2007 Mar 15; [Epub ahead of print]
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Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus.
Chandrasekar R, Kiran U, Weerakkody AN.
BJOG. 2007 Mar;114(3):375-6; author reply 376. No abstract available.
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Obesity and lifestyle management in polycystic ovary syndrome.
Hoeger KM.
Clin Obstet Gynecol. 2007 Mar;50(1):277-94.
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Pharmacologic therapy of polycystic ovary syndrome.
Dronavalli S, Ehrmann DA.
Clin Obstet Gynecol. 2007 Mar;50(1):244-54.
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The metabolic syndrome in polycystic ovary syndrome.
Essah PA, Wickham EP, Nestler JE.
Clin Obstet Gynecol. 2007 Mar;50(1):205-25.
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Effects of medical therapy on insulin resistance and the cardiovascular system in polycystic ovary syndrome.
Meyer C, McGrath BP, Teede HJ.
Diabetes Care. 2007 Mar;30(3):471-8.
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Androgen excess and cardiovascular risk.
Rizzo M, Rini GB, Carmina E.
Minerva Endocrinol. 2007 Mar;32(1):67-71.
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Polycystic ovarian syndrome: the commonest cause of hyperandrogenemia in women as a risk factor for metabolic syndrome.
Diamanti-Kandarakis E, Christakou C, Kandarakis H.
Minerva Endocrinol. 2007 Mar;32(1):35-47.
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Pediatrics
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Overweight, family history of diabetes and attending schools of lower academic grading are independent predictors for metabolic syndrome in Hong Kong Chinese adolescents.
Ozaki R, Qiao Q, Wong GW, Chan MH, So WY, Tong PC, Ho CS, Ko GT, Kong AP, Lam CW, Tuomilehto J, Chan JC.
Arch Dis Child. 2007 Mar;92(3):224-8. Epub 2006 Nov 6.
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Relationship between C-reactive protein and atherosclerotic risk factors and oxidative stress markers among young persons 10-18 years old.
Kelishadi R, Sharifi M, Khosravi A, Adeli K.
Clin Chem. 2007 Mar;53(3):456-64. Epub 2007 Jan 26.
View
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Identifying children at risk for polycystic ovary syndrome.
Rosenfield RL.
J Clin Endocrinol Metab. 2007 Mar;92(3):787-796. Epub 2006 Dec 19.
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Prothrombotic State
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Venous thromboembolism--a manifestation of the metabolic syndrome.
Ay C, Tengler T, Vormittag R, Simanek R, Dorda W, Vukovich T, Pabinger I.
Haematologica. 2007 Mar;92(3):374-80.
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The metabolic syndrome and the risk of thrombosis.
Dentali F, Romualdi E, Ageno W.
Haematologica. 2007 Mar;92(3):297-9. No abstract available.
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Risk Factors
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Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?
Nisoli E, Clementi E, Carruba MO, Moncada S.
Circ Res. 2007 Mar 30;100(6):795-806. Review.
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Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals.
Wang TJ, Larson MG, Keyes MJ, Levy D, Benjamin EJ, Vasan RS.
Circulation. 2007 Mar 20;115(11):1345-53. Epub 2007 Mar 5.
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LRP6 mutation in a family with early coronary disease and metabolic risk factors.
Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP.
Science. 2007 Mar 2;315(5816):1278-82.
View
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Multiple risk factors for cardiovascular disease and diabetes mellitus.
Smith SC Jr.
Am J Med. 2007 Mar;120(3 Suppl 1):S3-S11. Review.
View
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Therapeutic options for modifying cardiometabolic risk factors.
Aronne LJ.
Am J Med. 2007 Mar;120(3 Suppl 1):S26-34. Review.
View
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Determinants and definition of abdominal obesity as related to risk of diabetes, metabolic syndrome and coronary disease in
Turkish men: a prospective cohort study.
Onat A, Uyarel H, Hergenc G, Karabulut A, Albayrak S, Can G.
Atherosclerosis. 2007 Mar;191(1):182-90. Epub 2006 May 6.
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Increased arterial stiffness in remote Indigenous Australians with high risk of cardiovascular disease.
Maple-Brown LJ, Piers LS, O'Rourke MF, Celermajer DS, O'Dea K.
J Hypertens. 2007 Mar;25(3):585-91.
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Predictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based study.
Onat A, Sari I, Hergenc G, Yazici M, Uyarel H, Can G, Sansoy V.
Metabolism. 2007 Mar;56(3):348-56.
View
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Relationship between obesity and several cardiovascular disease risk factors in apparently healthy Korean individuals: comparison of body mass index and waist circumference.
Chul Sung K, Ryu S, Reaven GM; Health Screening Group at Kangbuk Samsung Hospital.
Metabolism. 2007 Mar;56(3):297-303.
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High cardiovascular fitness is associated with low metabolic risk score in children: the European Youth Heart Study.
Ruiz JR, Ortega FB, Rizzo NS, Villa I, Hurtig-Wennlof A, Oja L, Sjostrom M.
Pediatr Res. 2007 Mar;61(3):350-5.
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Sleep Disorders
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Obstructive sleep apnea: an update on mechanisms and cardiovascular consequences.
Wolf J, Lewicka J, Narkiewicz K.
Nutr Metab Cardiovasc Dis. 2007 Mar;17(3):233-40. Epub 2007 Feb 20. Review.
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Obesity, metabolic syndrome and sleep apnoea: all pro-inflammatory states.
Alam I, Lewis K, Stephens JW, Baxter JN.
Obes Rev. 2007 Mar;8(2):119-27. Review.
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Pediatric sleep apnea: implications of the epidemic of childhood overweight.
Ievers-Landis CE, Redline S.
Am J Respir Crit Care Med. 2007 Mar 1;175(5):436-41. Epub 2006 Dec 7. Review.
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