August 2007
Volume 2, issue 8


The Metabolic Syndrome Institute Literature Watch features the latest articles on the metabolic syndrome. Click on the links below to view the abstracts for each article.

Adipokines

  • Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease.
    Curr Opin Lipidol. 2007 Jun;18(3):263-70.
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  • Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis.
    Clin Chim Acta. 2007 Jun 16; [Epub ahead of print]
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  • Adipokines oversecreted by omental adipose tissue in human obesity.
    Am J Physiol Endocrinol Metab. 2007 Jun 19; [Epub ahead of print]
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Adipose Tissue Disorders

  • Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7.
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  • Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.
    Circulation. 2007 Jul 3;116(1):39-48. Epub 2007 Jun 18.
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Cardiovascular Disease

  • Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes.
    Diabetes. 2007 Jun;56(6):1718-26.
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  • Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000.
    Diabetes Care. 2007 Jun;30(6):1533-8.
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  • Carotid atherosclerosis associated to metabolic syndrome but not BMI in healthy menopausal women.
    Diabetes Res Clin Pract. 2007 Jun;76(3):378-82.
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  • Management of dyslipidemia in the metabolic syndrome.
    Cardiovasc Hematol Disord Drug Targets. 2007 Jun;7(2):99-108.
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  • Endothelial lipase and the metabolic syndrome.
    Curr Opin Lipidol. 2007 Jun;18(3):298-303.
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Diabetes

  • Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects.
    Int J Obes (Lond). 2007 Jun 26
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  • Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients.
    Atherosclerosis. 2007 Jun 4; [Epub ahead of print]
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Diet, Nutrition and Metabolism

  • Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults.
    Diabetes Care. 2007 Jun;30(6):1549-55. Epub 2007 Mar 10.
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  • Increased blood pressure reactivity to dietary salt in patients with the metabolic syndrome.
    J Hum Hypertens. 2007 Jun;21(6):438-44. Epub 2007 Feb 1.
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  • Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms.
    Nutr Rev. 2007 Jun;65(6 Pt 2):S13-23.
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Drug Therapy

  • Metabolic effects of telmisartan and irbesartan in type 2 diabetic patients with metabolic syndrome treated with rosiglitazone.
    J Clin Pharm Ther. 2007 Jun;32(3):261-8.
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  • Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients.
    Atherosclerosis. 2007 Jun 4; [Epub ahead of print]
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  • Drug discovery in the metabolic syndrome: context and some recent developments.
    Expert Opin Ther Targets. 2007 Jun;11(6):801-8.
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Epidemiology

  • Insulin resistance and the metabolic syndrome-or the pitfalls of epidemiology.
    Diabetologia. 2007 Aug;50(8):1576-1586. Epub 2007 Jun 26.
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  • The metabolic syndrome and vascular disease in Asia.
    Cardiovasc Hematol Disord Drug Targets. 2007 Jun;7(2):79-85.
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  • Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance.
    Diabetes Care. 2007 Jun;30(6):1527-32.
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  • Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study.
    Diabetes Care. 2007 Jun;30(6):1430-6. Epub 2007 Mar 2.
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  • Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans.
    Diabetologia. 2007 Jun;50(6):1156-60. Epub 2007 Mar 27.
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  • Metabolic syndrome in connection with BMI in young Finnish male adults.
    Diabetes Res Clin Pract. 2007 Jun;76(3):404-9. Epub 2006 Oct 24.
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  • Clustering of long-term trends in metabolic syndrome variables from childhood to adulthood in Blacks and Whites: The Bogalusa Heart Study.
    Am J Epidemiol. 2007 Jun 14; [Epub ahead of print]
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  • The prevalence of metabolic syndrome in various populations.
    Am J Med Sci. 2007 Jun;333(6):362-71.
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  • Body mass index and the prevalence of metabolic syndrome among children and adolescents in two Mexican populations.
    J Adolesc Health. 2007 Jun;40(6):521-6. Epub 2007 Mar 21.
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Exercise & Physical Activity

  • The metabolic syndrome: prevalence and association to leisure-time and work-related physical activity in 60-year-old men and women.
    Nutr Metab Cardiovasc Dis. 2007 Jun;17(5):349-57.
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  • Lifestyle plus exercise intervention improves metabolic syndrome markers without change in adiponectin in obese girls.
    Ann Nutr Metab. 2007 Jun 18;51(3):197-203 [Epub ahead of print]
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  • Body composition, metabolic syndrome and testosterone in ageing men.
    Int J Impot Res. 2007 Jun 7; [Epub ahead of print]
    Veiw

Genetics

  • The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome.
    J Membr Biol. 2006 Nov;214(1-2):91-8. Epub 2007 Jun 2.
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  • Cholesterol synthesis prevails over absorption in metabolic syndrome.
    Transl Res. 2007 Jun;149(6):310-6. Epub 2007 May 23.
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  • Chylomicron and apoB48 metabolism in the JCR:LA corpulent rat, a model for the metabolic syndrome.
    Biochem Soc Trans. 2007 Jun;35(Pt 3):477-81.
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  • Inherited lipodystrophies and the metabolic syndrome.
    Clin Endocrinol (Oxf). 2007 Jun 11; [Epub ahead of print]
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Hypertension

  • Metabolic syndrome in hypertensive patients: correlation between anthropometric data and laboratory findings.
    Diabetes Care. 2007 Jun;30(6):1624-6.
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  • Hypertension in people with diabetes and the metabolic syndrome: pathophysiologic insights and therapeutic update.
    Curr Diab Rep. 2007 Jun;7(3):208-17.
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Insulin Sensitivity / Insulin Resistance

  • Insulin resistance and the metabolic syndrome-or the pitfalls of epidemiology.
    Diabetologia. 2007 Aug;50(8):1576-86. Epub 2007 Jun 26.
    View
  • Microcirculation and the metabolic syndrome.
    Microcirculation. 2007 Jun;14(4):403-38.
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  • Insulin resistance and salt-sensitive hypertension in metabolic syndrome.
    Nephrol Dial Transplant. 2007 Jun 30; [Epub ahead of print] No abstract available.
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  • Cortisol and insulin in depression and metabolic syndrome.
    Psychoneuroendocrinology. 2007 Jun 7; [Epub ahead of print] No abstract available.
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Non-Alcoholic Fatty Liver Disease

  • How should we manage patients with non-alcoholic fatty liver disease in 2007?
    J Gastroenterol Hepatol. 2007 Jun;22(6):801-8.
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  • How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences?
    J Gastroenterol Hepatol. 2007 Jun;22(6):788-93.
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  • What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific?
    J Gastroenterol Hepatol. 2007 May 13; [Epub ahead of print]
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  • Non-alcoholic fatty liver disease in the Asia-Pacific region: Definitions and overview of proposed guidelines.
    J Gastroenterol Hepatol. 2007 Jun;22(6):778-87.
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  • Clinical significance of fatty liver associated with metabolic syndrome.
    Hepatol Res. 2007 Sep;37(9):711-21. Epub 2007 Jun 15.
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  • Liver fat in the metabolic syndrome.
    J Clin Endocrinol Metab. 2007 Jun 26; [Epub ahead of print]
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Obesity

  • Type 2 diabetes and metabolic syndrome are associated with increased expression of 11beta-hydroxysteroid dehydrogenase 1 in obese subjects.
    Int J Obes (Lond). 2007 Jun 26; [Epub ahead of print]
    View
  • Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000.
    Diabetes Care. 2007 Jun;30(6):1533-8.
    View

PCOS / Menopause / Metabolic Syndrome in Women

  • The adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and proinflammatory markers.
    Metabolism. 2007 Jun;56(6):766-71.
    View
  • Prevalence of the metabolic syndrome and its components in Brazilian women with polycystic ovary syndrome.
    Fertil Steril. 2007 Jun 1; [Epub ahead of print]
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  • Carotid atherosclerosis associated to metabolic syndrome but not BMI in healthy menopausal women.
    Diabetes Res Clin Pract. 2007 Jun;76(3):378-82. Epub 2006 Oct 10.
    View

Pediatrics

  • The metabolic syndrome in children and adolescents.
    Lancet. 2007 Jun 23;369(9579):2059-61. No abstract available.
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  • Is there a single underlying factor for the metabolic syndrome in adolescents? A confirmatory factor analysis.
    Diabetes Care. 2007 Jun;30(6):1556-61.
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  • Obesity and the metabolic syndrome in korean adolescents.
    J Korean Med Sci. 2007 Jun;22(3):513-7.
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  • Is Presence of Hypertension in Obese Children Correlate with the Criteria of Metabolic Syndrome?
    J Trop Pediatr. 2007 Jun 27; [Epub ahead of print]
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  • Metabolic syndrome in obese children born large for gestational age.
    Indian J Pediatr. 2007 Jun;74(6):561-5.
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Prothrombotic State

  • Stress mechanisms and metabolic complications.
    Horm Metab Res. 2007 Jun;39(6):430-8.
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  • Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy.
    Am J Physiol Renal Physiol. 2007 Jun 27; [Epub ahead of print]
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  • Interrelationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men.
    J Thromb Haemost. 2007 Jun 1; [Epub ahead of print]
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Risk Factors

  • Interrelationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men.
    J Thromb Haemost. 2007 Jun 1; [Epub ahead of print]
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  • Factor analysis of cardiovascular risk clustering in pediatric metabolic syndrome: CASPIAN study.
    Ann Nutr Metab. 2007 Jun 18;51(3):208-215 [Epub ahead of print]
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  • The prevalence of the metabolic syndrome and its risk factors in a middle-aged Swedish population - Mainly a function of overweight?
    Eur J Cardiovasc Nurs. 2007 Jun 21; [Epub ahead of print]
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  • Metabolic syndrome and mortality in stable coronary heart disease: Relation to gender.
    Int J Cardiol. 2007 Jun 11
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  • All-cause mortality associated with specific combinations of the metabolic syndrome according to recent definitions.
    Diabetes Care. 2007 Jun 11; [Epub ahead of print]
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Sleep Disorders

  • Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents.
    J Pediatr. 2007 Jun;150(6):608-12.
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  • Clinical perspective of obstructive sleep apnea-induced cardiovascular complications.
    Antioxid Redox Signal. 2007 Jun;9(6):701-10. Review..
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Coordinated by Dr. Scott Grundy, President of the IAS