January 2008
Volume 3,
issue 1


The Metabolic Syndrome Institute Literature Watch features the latest articles on the metabolic syndrome. Click on the links below to view the abstracts for each article.

Adipose Tissue Disorders

  • Adipose Tissue: A Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA).
    (Maiorana A, et.al. Rev Diabet Stud. 2007 Fall;4(3):134-46. Epub 2007 Nov 10.)
    View Abstract

Cancer

  • Association between androgen-deprivation therapy and incidence of diabetes among males with prostate cancer.
    (Lage MJ, et.al. Urology. 2007 Dec;70(6):1104-8.)
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  • Disorders of glucose metabolism and risk of oral cancer.
    (Suba Z, et.al. Fogorv Sz. 2007 Oct;100(5):250-7, 243-9. Review. English, Hungarian.)
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  • Metabolic syndrome and cancer risk.
    (Russo A, et.al. Eur J Cancer. 2007 Dec 3; [Epub ahead of print])
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  • Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.
    (Girroir EE, et.al. Toxicology. 2008 Jan 14;243(1-2):236-43. Epub 2007 Nov 4.)
    View Abstract
  • Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease?
    (Oeffinger KC.Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):462-7; discussion 468.)
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Cardiovascular Disease

  • Depression, the Metabolic Syndrome and Cardiovascular Risk.
    (Vaccarino V, et.al. Psychosom Med. 2007 Dec 24; [Epub ahead of print])
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  • Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in framingham offspring participants without clinical evidence of cardiovascular disease.
    (Hamburg NM, et.al. Am J Cardiol. 2008 Jan 1;101(1):82-8.)
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  • Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome.
    (Gómez Rosso L, et.al. Atherosclerosis. 2007 Dec 18; [Epub ahead of print])
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  • Vitamin D and cardiovascular disease risk.
    (Michos ED, et.al. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7-12.)
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Diabetes

  • Metabolic Syndrome and Vascular Alterations in Normotensive Subjects at Risk of Diabetes Mellitus.
    (Ghiadoni L, et.al. Hypertension. 2007 Dec 24; [Epub ahead of print])
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  • Metabolic risk factors, endothelial dysfunction, and erectile dysfunction in men with diabetes.
    (Palumbo PJ.Am J Med Sci. 2007 Dec;334(6):466-80.)
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  • Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.
    (Maassen JA, et.al. Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):693-7.)
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  • Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes.
    (Osawa H, et.al. Clin Endocrinol (Oxf). 2007 Dec 6; [Epub ahead of print])
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  • Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration.
    (Rhee EJ, et.al. Endocr J. 2007 Dec 4; [Epub ahead of print])
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  • Heart failure in diabetes and related conditions.
    (Kamalesh M.J Card Fail. 2007 Dec;13(10):861-73.)
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  • Modulation of glucocorticoid action and the treatment of type-2 diabetes.
    (Tomlinson JW, et.al. Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):607-19.)
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  • Atorvastatin efficacy in the prevention of cardiovascular events in patients with diabetes mellitus and/or metabolic syndrome.
    (Arca M.Drugs. 2007;67 Suppl 1:43-54.)
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Diet, Nutrition and Metabolism

  • Clinical Benefit of a Short Term Dietary Oatmeal Intervention in Patients with Type 2 Diabetes and Severe Insulin Resistance: A Pilot Study.
    (Lammert A, et.al. Exp Clin Endocrinol Diabetes. 2007 Dec 20; [Epub ahead of print])
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  • Postnatal programming of glucocorticoid metabolism in rats modulates high-fat diet-induced regulation of visceral adipose tissue glucocorticoid exposure and sensitivity, and adiponectin and pro-inflammatory adipokines gene expression in adulthood.
    (Boullu-Ciocca S, et.al. Diabetes. 2007 Dec 5; [Epub ahead of print])
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  • Nateglinide prevents fatty liver through up-regulation of lipid oxidation pathway in Goto-Kakizaki rats on a high-fat diet.
    (Mine T, et.al. Metabolism. 2008 Jan;57(1):140-8.)
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Epidemiology

  • Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community.
    (Chien KL, et.al. Clin Chem. 2007 Dec 18; [Epub ahead of print])
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  • The Metabolic Syndrome and Dyslipidemia Among Asian Indians: A Population With High Rates of Diabetes and Premature Coronary Artery Disease.
    (Enas EA, et.al. J Cardiometab Syndr. 2007 Fall;2(4):267-275.)
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  • Diabetes mellitus in Asian Indian children and adolescents.
    (Nandkeoliar MK, et.al. J Pediatr Endocrinol Metab. 2007 Oct;20(10):1109-14.)
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  • Apolipoprotein A5 IVS3+476A Allelic Variant Associates With Increased Trigliceride Levels and Confers Risk for Development of Metabolic Syndrome in Hungarians.
    (Kisfali P, et.al. Circ J. 2008 Jan;72(1):40-3.)
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Exercise / Physical Activity

  • Exercise Training Amount and Intensity Effects on Metabolic Syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise).
    (Johnson JL, et.al. Am J Cardiol. 2007 Dec 15;100(12):1759-66. Epub 2007 Oct 29.)
    View Abstract
  • The Italian Diabetes and Exercise Study (IDES): Design and methods for a prospective Italian multicentre trial of intensive lifestyle intervention in people with type 2 diabetes and the metabolic syndrome.
    (Balducci S, et.al. Nutr Metab Cardiovasc Dis. 2007 Nov 29; [Epub ahead of print])
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  • Associations between abdominal adiposity, exercise, morbidity, and mortality.
    (Kuk JL.Appl Physiol Nutr Metab. 2007 Dec;32(6):1210-1.)
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Genetics

  • The Effect of Plasminogen Activator Inhibitor-1 675 4G/5G Polymorphism on PAI-1 Gene Expression and Adipocyte Differentiation.
    (Ozel Demiralp D, et.al. Clin Appl Thromb Hemost. 2007 Dec 26; [Epub ahead of print])
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  • Association of Angiotensin-converting enzyme gene insertion/deletion polymorphism with metabolic syndrome in iranians with type 2 diabetes mellitus.
    (Nikzamir A, et.al. Arch Iran Med. 2008 Jan;11(1):3-9.)
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  • USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.
    (Auro K, et.al. Diabetologia. 2007 Dec 21; [Epub ahead of print])
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  • Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.
    (Pollex RL, et.al. BMC Med Genet. 2007 Dec 20;8(1):80 [Epub ahead of print])
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  • Gene expression profile in obesity and type 2 diabetes mellitus.
    (Das UN, et.al. Lipids Health Dis. 2007 Dec 14;6(1):35 [Epub ahead of print])
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  • Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.
    (Scott EM, et.al. Int J Obes (Lond). 2007 Dec 11; [Epub ahead of print])
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Hypertension

  • Relationship Between the Metabolic Syndrome and the Development of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2).
    (Cheung BM, et.al. Am J Hypertens. 2008 Jan;21(1):17-22.)
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  • Undiagnosed obesity in hypertension: Clinical and therapeutic implications.
    (Romero R, et.al. Blood Press. 2007;16(6):347-53.)
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Insulin Resistance / Insulin Sensitivity

  • Association between proinsulin, insulin, proinsulin/insulin ratio, and insulin resistance status with the metabolic syndrome.
    (Pivatto I, et.al. Arq Bras Endocrinol Metabol. 2007 Oct;51(7):1128-1133.)
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  • Metabolic consequences of hyperglycemia and insulin resistance.
    (Jellinger PS.Clin Cornerstone. 2007;8 Suppl 7:S30-42.)
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  • Melatonin-insulin interactions in patients with metabolic syndrome.
    (Robeva R, et.al. J Pineal Res. 2008 Jan;44(1):52-6.)
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  • FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases.
    (Ni YG, et.al. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20517-22. Epub 2007 Dec 12.)
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  • Insulin resistance and metabolic syndrome in patients with NAFLD but without diabetes: effect of a 6 month regime intervention.
    (Cankurtaran M, et.al. Acta Gastroenterol Belg. 2007 Jul-Sep;70(3):253-9.)
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  • ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells.
    (Allagnat F, et.al. J Biol Chem. 2007 Dec 11; [Epub ahead of print])
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  • Role of adipocytokines in obesity-associated insulin resistance.
    (Zou C, et.al. J Nutr Biochem. 2007 Nov 26; [Epub ahead of print])
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  • Inflammation and insulin resistance.
    (de Luca C, et.al. FEBS Lett. 2008 Jan 9;582(1):97-105. Epub 2007 Nov 29.)
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  • Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults.
    (Shariatpanahi ZV, et.al. Br J Nutr. 2007 Dec 6;:1-5 [Epub ahead of print])
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  • Hyperlipidemia is associated with altered levels of insulin-like growth factor-I.
    (Malík J, et.al. Physiol Res. 2007 Nov 30; [Epub ahead of print])
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Metabolic Syndrome in Women

  • Confusion in Revascularization: Are Women Different and Why?
    (Dullum MK, et.al. Cardiol Rev. 2008 January/February;16(1):30-35.)
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  • Endothelium-dependent vasodilatation in formerly preeclamptic women correlates inversely with body mass index and varies independently of plasma volume.
    (Lommerse T, et.al. Reprod Sci. 2007 Dec;14(8):765-70.)
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  • Uric acid: A surrogate of insulin resistance in older women.
    (Chen LK, et.al. Maturitas. 2007 Dec 12; [Epub ahead of print])
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  • Metabolic syndrome: do clinical criteria identify similar individuals among overweight premenopausal women?
    (Alhassan S, et.al. Metabolism. 2008 Jan;57(1):49-56.)
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  • Effects of spironolactone on glucose transport and interleukin-6 secretion in adipose cells of women.
    (Corbould A.Horm Metab Res. 2007 Dec;39(12):915-8.)
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  • Behavior of insulin sensitivity and its relation to leptin and tumor necrosis factor-alpha in obese women undergoing liposuction: 6-month follow-up.
    (Robles-Cervantes JA, et.al. Obes Surg. 2007 Sep;17(9):1242-7.)
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  • The increasing prevalence of metabolic syndrome among Finnish men and women over a decade.
    (Hu G, et.al. J Clin Endocrinol Metab. 2007 Dec 11; [Epub ahead of print])
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  • Management of cardiovascular risk in the perimenopausal women: a consensus statement of European cardiologists and gynecologists.
    (Collins P, et.al. Climacteric. 2007 Dec;10(6):508-26.)
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  • Gestational diabetes, inflammation, and late vascular disease.
    (Volpe L, et.al. J Endocrinol Invest. 2007 Nov;30(10):873-9.)
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  • Body iron stores in relation to the metabolic syndrome, glycemic control and complications in female patients with type 2 diabetes.
    (Mojiminiyi OA, et.al. Nutr Metab Cardiovasc Dis. 2007 Dec 4; [Epub ahead of print])
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Non-Alcoholic Fatty Liver Disease

  • Plasma Plasminogen Activator Inhibitor-1 Levels and Nonalcoholic Fatty Liver in Individuals With Features of Metabolic Syndrome.
    (de Larranaga G, et.al. Clin Appl Thromb Hemost. 2007 Dec 26; [Epub ahead of print])
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  • Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach.
    (Bellentani S, et.al. Hepatology. 2007 Dec 20; [Epub ahead of print])
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  • Nonalcoholic Fatty Liver Disease Induced by Leuprorelin Acetate.
    (Gabbi C, et.al. J Clin Gastroenterol. 2008 Jan;42(1):107-110.)
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  • Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis.
    (Manco M, et.al. Int J Obes (Lond). 2007 Dec 18; [Epub ahead of print])
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  • Metabolic syndrome and non-alcoholic fatty liver disease: Asian definitions and Asian studies.
    (Fan JG, et.al. Hepatobiliary Pancreat Dis Int. 2007 Dec;6(6):572-8.)
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  • Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease.
    (Puri P, et.al. Gastroenterology. 2007 Oct 26; [Epub ahead of print])
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  • Nonalcoholic Fatty Liver Disease: Pathogenesis and Potential for Nuclear Receptors as Therapeutic Targets.
    (George J, et.al. Mol Pharm. 2007 Dec 12; [Epub ahead of print])
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  • SHOULD NONALCOHOLIC FATTY LIVER DISEASE BE INCLUDED IN THE DEFINITION OF METABOLIC SYNDROME? A CROSS-SECTIONAL COMPARISON WITH ATP III CRITERIA IN NONOBESE NONDIABETIC SUBJECTS.
    (Musso G, et.al. Diabetes Care. 2007 Dec 4; [Epub ahead of print])
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  • Liver fattening during feast and famine: An evolutionary paradox.
    (van Ginneken VJ.Med Hypotheses. 2007 Dec 1; [Epub ahead of print])
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Obesity

  • Pharmacotherapeutic targeting of the endocannabinoid signaling system: Drugs for obesity and the metabolic syndrome.
    (Vemuri VK, et.al. Physiol Behav. 2007 Nov 21; [Epub ahead of print])
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  • Overweight adolescents: a group at risk for metabolic syndrome (tehran adolescent obesity study).
    (Moayeri H, et.al. Arch Iran Med. 2008 Jan;11(1):10-5.)
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  • Inflammation, obesity, and fatty acid metabolism: influence of n-3 polyunsaturated fatty acids on factors contributing to metabolic syndrome.
    (Robinson LE, et.al. Appl Physiol Nutr Metab. 2007 Dec;32(6):1008-1024.)
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  • Effective cut-off values of waist circumference to detect the clustering of cardiovascular risk factors of metabolic syndrome in Japanese men and women.
    (Lee JS, et.al. Diab Vasc Dis Res. 2007 Dec;4(4):340-5.)
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Pediatrics/ Metabolic Syndrome in Children

  • Prevalence of the Metabolic Syndrome Among U.S. Adolescents Using the Definition from the International Diabetes Federation.
    (Ford ES, et.al. Diabetes Care. 2007 Dec 10; [Epub ahead of print])
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  • Impaired glucose tolerance and risk factors for progression to type 2 diabetes in youth.
    (Weiss R.Pediatr Diabetes. 2007 Dec;8 Suppl 9:70-5.)
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  • Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study.
    (Mattsson N, et.al. Eur Heart J. 2007 Dec 15; [Epub ahead of print])
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Risk Factors

  • Reduced high-molecular weight adiponectin and elevated hsCRP are synergistic risk factors for metabolic syndrome in a large scale middle-aged to elderly population: the J-SHIPP study.
    (Tabara Y, et.al. J Clin Endocrinol Metab. 2007 Dec 26; [Epub ahead of print])
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  • Metabolic syndrome: are we at risk?
    (Paudel B.Nepal Med Coll J. 2007 Sep;9(3):204-11.)
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  • Impact of metabolic syndrome risk factors in first-degree relatives of type 2 diabetic patients.
    (Siewert S, et.al. Rev Diabet Stud. 2007 Fall;4(3):177-84. Epub 2007 Nov 10.)
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  • Metabolic syndrome and ischemic stroke risk: northern Manhattan study.
    (Boden-Albala B, et.al. Stroke. 2008 Jan;39(1):30-5. Epub 2007 Dec 6.)
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  • Metabolic syndrome: identifying the risk factors.
    (Lottenberg SA, et.al. J Pediatr (Rio J). 2007 Nov;83(5 Suppl):S204-8.)
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  • Metabolic syndrome and risk of developing chronic kidney disease in Japanese adults.
    (Tozawa M, et.al. Hypertens Res. 2007 Oct;30(10):937-43.)
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  • Prognostic Relevance of Metabolic Syndrome in Hypertensive Patients at Low-to-Medium Risk.
    (Pierdomenico SD, et.al. Am J Hypertens. 2007 Dec;20(12):1291-1296.)
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  • Body-mass index, waist-size, waist-hip ratio and cardiovascular risk factors in urban subejcts.
    (Gupta R, et.al. J Assoc Physicians India. 2007 Sep;55:621-7.)
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Sleep Disorders

  • The reciprocal interaction between sleep and type 2 diabetes mellitus: facts and perspectives.
    (Martins RC, et.al. Braz J Med Biol Res. 2007 Nov 27; [Epub ahead of print])
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Coordinated by Dr. Scott Grundy, Past-President of the IAS