February 2008
Volume 3,
issue 2


The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adipose Tissue Disorders

  • Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury.
    (Maruyama Y, et.al. Spinal Cord. 2008 Jan 22; [Epub ahead of print])
    View Abstract
  • Lipid goals in metabolic syndrome and diabetes.
    (Colhoun HM.Curr Atheroscler Rep. 2007 Oct;9(4):286-95.)
    View Abstract
  • URB is abundantly expressed in adipose tissue and dysregulated in obesity.
    (Okada T, et.al. Biochem Biophys Res Commun. 2008 Mar 7;367(2):370-6. Epub 2008 Jan 4.)
    View Abstract
  • Role of interleukin-6 signalling in glucose and lipid metabolism.
    (Glund S, et.al. Acta Physiol (Oxf). 2008 Jan;192(1):37-48.)
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Cancer

  • A randomized phase II trial of preoperative exercise to reduce operative risk in gastric cancer patients with metabolic syndrome: Adjuvant exercise for general elective surgery (AEGES) study group.
    (Cho H, et.al. Jpn J Clin Oncol. 2008 Jan 17; [Epub ahead of print])
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  • Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation.
    (Annaloro C, et.al. Bone Marrow Transplant. 2008 Jan 14; [Epub ahead of print])
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Cardiovascular Disease

  • The metabolic syndrome and mortality: the Singapore Cardiovascular Cohort Study.
    (Lee J, et.al. Clin Endocrinol (Oxf). 2008 Jan 15; [Epub ahead of print])
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  • Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes.
    (Oltman CL, et.al. Vascul Pharmacol. 2008 Jan;48(1):47-53. Epub 2007 Nov 29.)
    View Abstract
  • Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample. The Framingham Heart Study.
    (Rosito GA, et.al. Circulation. 2008 Jan 22; [Epub ahead of print])
    View Abstract
  • Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low high-density lipoprotein cholesterol.
    (Dullaart RP, et.al. Eur J Endocrinol. 2008 Jan;158(1):53-60.)
    View Abstract
  • Elasticity indices of large and small arteries in relation to the metabolic syndrome in chinese.
    (Ge JY, et.al. Am J Hypertens. 2008 Jan 10; [Epub ahead of print])
    View Abstract
  • Cardiovascular disease risk factors in polycystic ovary syndrome.
    (Dokras A.Semin Reprod Med. 2008 Jan;26(1):39-44.)
    View Abstract
  • Comparative associations of adiposity measures with cardiometabolic risk burden in asymptomatic subjects.
    (Dervaux N, et.al. Atherosclerosis. 2008 Jan 10; [Epub ahead of print])
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  • Carotid artery intima-media thickness in nonalcoholic fatty liver disease.
    (Fracanzani AL, et.al. Am J Med. 2008 Jan;121(1):72-8.)
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  • Work stress and coronary heart disease: what are the mechanisms?
    (Chandola T, et.al. Eur Heart J. 2008 Jan 23; [Epub ahead of print])
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  • Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.
    (Bugger H, et.al. Clin Sci (Lond). 2008 Feb;114(3):195-210.)
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Diabetes

  • Neither the presence of metabolic syndrome as defined by the IDF guideline nor an increased waist circumference increased the risk of microvascular or macrovascular complications in Japanese patients with type 2 diabetes.
    (Iwasaki T, et.al. Diabetes Res Clin Pract. 2008 Jan 18; [Epub ahead of print])
    View Abstract
  • Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later.
    (Morrison JA, et.al. J Pediatr. 2008 Feb;152(2):201-6. Epub 2007 Nov 5.)
    View Abstract
  • Adult nontwin sib concordance rates for type 2 diabetes, hypertension and metabolic syndrome among Asian Indians: the Indian Atherosclerosis Research Study.
    (Shanker J, et.al. Vasc Health Risk Manag. 2007;3(6):1063-8.)
    View Abstract
  • The metabolic syndrome in type 1 diabetes: does it exist and does it matter?
    (McGill M, et.al. J Diabetes Complications. 2008 Jan-Feb;22(1):18-23.)
    View Abstract
  • Metabolic syndrome is not associated with reduction in aortic distensibility in subjects with type 2 diabetes mellitus.
    (Tentolouris N, et.al. Cardiovasc Diabetol. 2008 Jan 2;7(1):1 [Epub ahead of print])
    View Abstract
  • Treatment of cardiovascular dysfunction associated with the metabolic syndrome and type 2 diabetes.
    (Oltman CL, et.al. Vascul Pharmacol. 2008 Jan;48(1):47-53. Epub 2007 Nov 29.)
    View Abstract
  • HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes.
    (Carper MJ, et.al. Am J Physiol Endocrinol Metab. 2008 Jan 2; [Epub ahead of print])
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Diet, Nutrition and Metabolism

  • Circulating antioxidant defences are decreased in healthy people after a high-fat meal.
    (Cardona F, et.al. Br J Nutr. 2008 Jan 10;:1-5 [Epub ahead of print])
    View Abstract
  • The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome.
    (Katcher HI, et.al. Am J Clin Nutr. 2008 Jan;87(1):79-90.)
    View Abstract
  • Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort.
    (Athyros VG, et.al. Angiology. 2007 Dec-2008 Jan;58(6):689-97.)
    View Abstract
  • Diet-induced central obesity and insulin resistance in rabbits.
    (Zhao S, et.al. J Anim Physiol Anim Nutr (Berl). 2008 Feb;92(1):105-111.)
    View Abstract
  • Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects.
    (Tay J, et.al. J Am Coll Cardiol. 2008 Jan 1;51(1):59-67.)
    View Abstract
  • Phytochemical composition and metabolic performance-enhancing activity of dietary berries traditionally used by native North Americans.
    (Burns Kraft TF, et.al. J Agric Food Chem. 2008 Jan 23; [Epub ahead of print])
    View Abstract
  • Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome.
    (Tsuda T.J Agric Food Chem. 2008 Jan 23; [Epub ahead of print])
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  • The association between dietary macronutrient intake and the prevalence of the metabolic syndrome.
    (Skilton MR, et.al. Br J Nutr. 2008 Jan 15;:1-8 [Epub ahead of print])
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  • Vitamin D, PTH, and the metabolic syndrome in severely obese subjects.
    (Rueda S, et.al. Obes Surg. 2008 Jan 4; [Epub ahead of print])
    View Abstract
  • Vitamin D, the renin-angiotensin system, and insulin resistance.
    (Rammos G, et.al. Int Urol Nephrol. 2008 Jan 10; [Epub ahead of print])
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  • Dietary therapy in polycystic ovary syndrome.
    (Moran LJ, et.al. Semin Reprod Med. 2008 Jan;26(1):85-92.)
    View Abstract
  • Dietary intake and the development of the metabolic syndrome. The Atherosclerosis Risk in Communities Study.
    (Lutsey PL, et.al. Circulation. 2008 Jan 22; [Epub ahead of print])
    View Abstract
  • Mediterranean diet and metabolic diseases.
    (Giugliano D, et.al. Curr Opin Lipidol. 2008 Feb;19(1):63-8.)
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Epidemiology

  • A prospective community-population-registry based cohort study of the association between betel-quid chewing and cardiovascular disease in men in Taiwan (KCIS no. 19).
    (Yen AM, et.al. Am J Clin Nutr. 2008 Jan;87(1):70-8.)
    View Abstract
  • Metabolic syndrome: An emerging public health problem in Iranian Women: Isfahan Healthy Heart Program.
    (Sarrafzadegan N, et.al. Int J Cardiol. 2008 Jan 9; [Epub ahead of print])
    View Abstract
  • Negative impact of metabolic syndrome on the responsiveness to sildenafil in Japanese men.
    (Suetomi T, et.al. J Sex Med. 2008 Jan 18; [Epub ahead of print])
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  • CARMELA: assessment of cardiovascular risk in seven Latin American cities.
    (Schargrodsky H, et.al. Am J Med. 2008 Jan;121(1):58-65.)
    View Abstract
  • Postprandial lipaemia, metabolic syndrome and LDL particle size in urbanised South African blacks with and without coronary artery disease.
    (Ntyintyane LM, et.al. QJM. 2008 Jan 14; [Epub ahead of print])
    View Abstract
  • Associations between trait anxiety, insulin resistance, and atherosclerosis in the elderly: A pilot cross-sectional study.
    (Narita K, et.al. Psychoneuroendocrinology. 2008 Jan 4; [Epub ahead of print])
    View Abstract
  • The metabolic syndrome and mortality: the Singapore Cardiovascular Cohort Study.
    (Lee J, et.al. Clin Endocrinol (Oxf). 2008 Jan 15; [Epub ahead of print])
    View Abstract
  • Metabolic syndrome pandemic.
    (Grundy SM.Arterioscler Thromb Vasc Biol. 2008 Jan 3; [Epub ahead of print])
    View Abstract
  • Association of the distal region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) gene with type 2 diabetes in an African American population enriched for nephropathy.
    (Keene KL, et.al. Diabetes. 2008 Jan 9; [Epub ahead of print])
    View Abstract
  • Quantitative linkage analysis for pancreatic B-cell function and insulin resistance in a large twin cohort.
    (Falchi M, et.al. Diabetes. 2008 Jan 3; [Epub ahead of print])
    View Abstract
  • Association between psoriasis and the metabolic syndrome. A cross-sectional study.
    (Cohen AD, et.al. Dermatology. 2008;216(2):152-5. Epub 2008 Jan 23.)
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Exercise / Physical Activity

  • Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study.
    (Ilanne-Parikka P, et.al. Diabetes Care. 2008 Jan 9; [Epub ahead of print])
    View Abstract
  • Lifestyle intervention in the management of metabolic syndrome: could we improve adherence issues?
    (Fappa E, et.al. Nutrition. 2008 Jan 15; [Epub ahead of print])
    View Abstract
  • DiabetAction: Changes in physical activity practice, fitness, and metabolic syndrome in type 2 diabetic and at-risk individuals.
    (Mathieu ME, et.al. Clin J Sport Med. 2008 Jan;18(1):70-75.)
    View Abstract
  • Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
    (Rector RS, et.al. Am J Physiol Gastrointest Liver Physiol. 2008 Jan 3; [Epub ahead of print])
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Genetics

  • Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations.
    (Legry V, et.al. Int J Obes (Lond). 2008 Jan 22; [Epub ahead of print])
    View Abstract
  • A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome.
    (Wong J, et.al. Diabetes Res Clin Pract. 2008 Jan 2; [Epub ahead of print])
    View Abstract
  • A common intron 2 polymorphism of the glucocorticoid receptor gene is associated with insulin resistance in men.
    (Syed AA, et.al. Clin Endocrinol (Oxf). 2008 Jan 10; [Epub ahead of print])
    View Abstract
  • Aerobic capacity-dependent differences in cardiac gene expression.
    (Bye A, et.al. Physiol Genomics. 2008 Jan 2; [Epub ahead of print])
    View Abstract
  • Association of SGK1 gene polymorphisms with type 2 diabetes.
    (Schwab M, et.al. Cell Physiol Biochem. 2008;21(1-3):151-60. Epub 2008 Jan 16.)
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Hypertension

  • The role of melatonin in the pathogenesis of hypertension in rats with metabolic syndrome.
    (Leibowitz A, et.al. Am J Hypertens. 2008 Jan 24; [Epub ahead of print])
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  • History of gestational hypertension is associated with the metabolic syndrome and masked hypertension but not arterial stiffness in women with essential hypertension.
    (Mahmud A, et.al. J Clin Hypertens (Greenwich). 2008 Jan;10(1):21-26.)
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  • Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.
    (Bailey SR, et.al. Am J Vet Res. 2008 Jan;69(1):122-9.)
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  • Hypertension and dyslipidaemia in obesity and insulin resistance: Pathophysiology, impact on atherosclerotic disease and pharmacotherapy.
    (Chapman MJ, et.al. Pharmacol Ther. 2007 Dec 14; [Epub ahead of print])
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Insulin Resistance / Insulin Sensitivity

  • The investigation and management of severe hyperandrogenism pre- and postmenopause: Non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin.
    (Vaikkakara S, et.al. Gynecol Endocrinol. 2008 Feb;24(2):87-92.)
    View Abstract
  • Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin esistance, adiponectin, and inflammatory biomarkers.
    (Lee S, et.al. J Pediatr. 2008 Feb;152(2):177-84. Epub 2007 Oct 22.)
    View Abstract
  • Impaired glucose tolerance and neuropathy.
    (Smith AG, et.al. Neurologist. 2008 Jan;14(1):23-29.)
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  • cGMP rescues mitochondrial dysfunction induced by glucose and insulin in myocytes.
    (Mitsuishi M, et.al. Biochem Biophys Res Commun. 2008 Jan 11; [Epub ahead of print])
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  • Insulin effect on adipose tissue adiponectin expression is regulated by the insulin resistance status of the patients.
    (Hernandez-Morante JJ, et.al. Clin Endocrinol (Oxf). 2008 Jan 15; [Epub ahead of print])
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Metabolic Syndrome in Women

  • Metabolic syndrome: An emerging public health problem in Iranian Women: Isfahan Healthy Heart Program.
    (Sarrafzadegan N, et.al. Int J Cardiol. 2008 Jan 9; [Epub ahead of print])
    View Abstract
  • Does polycystic ovary syndrome increase the disparity in metabolic syndrome and cardiovascular-related health for african-american women?
    (Coney P, et.al. Semin Reprod Med. 2008 Jan;26(1):35-8.)
    View Abstract
  • Polycystic ovary syndrome in the Indian Subcontinent.
    (Allahbadia GN, et.al. Semin Reprod Med. 2008 Jan;26(1):22-34.)
    View Abstract
  • A randomized controlled trial of therapeutic lifestyle modification in rural women with metabolic syndrome: a pilot study.
    (Oh EG, et.al. Metabolism. 2008 Feb;57(2):255-61.)
    View Abstract
  • Undernutrition and growth restriction in pregnancy.
    (Bergmann RL, et.al. Nestle Nutr Workshop Ser Pediatr Program. 2008;61:103-21.)
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  • Post-menopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: Results from the National Institutes of Health National Heart, Lung, and Blood Institute (NHLBI) Sponsored Women's Ischemia Syndrome Evaluation (WISE).
    (Shaw LJ, et.al. J Clin Endocrinol Metab. 2008 Jan 8; [Epub ahead of print])
    View Abstract
  • Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife-SWAN, the study of women's health across the nation.
    (Ram KT, et.al. Am J Obstet Gynecol. 2008 Jan 11; [Epub ahead of print])
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  • Intrauterine growth restriction in a rodent model and developmental programming of the metabolic syndrome: A critical appraisal of the experimental evidence.
    (Neitzke U, et.al. Placenta. 2008 Jan 18; [Epub ahead of print])
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Non-Alcoholic Fatty Liver Disease

  • Non-alcoholic fatty liver disease and the metabolic syndrome: An update.
    (Rector RS, et.al. World J Gastroenterol. 2008 Jan 14;14(2):185-92.)
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  • Nonalcoholic fatty liver disease and mitochondrial dysfunction.
    (Wei Y, et.al. World J Gastroenterol. 2008 Jan 14;14(2):193-9.)
    View Abstract
  • PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.
    (Vinciguerra M, et.al. Gastroenterology. 2008 Jan;134(1):268-80. Epub 2007 Oct 10.)
    View Abstract
  • The associations between birthweight and adult markers of liver damage and function.
    (Fraser A, et.al. Paediatr Perinat Epidemiol. 2008 Jan;22(1):12-21.)
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Obesity

  • Sensitivity and specificity of body mass index as a definition of the obesity component of metabolic syndrome.
    (Chakraborty BM, et.al. Coll Antropol. 2007 Dec;31(4):943-7.)
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  • Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury.
    (Maruyama Y, et.al. Spinal Cord. 2008 Jan 22; [Epub ahead of print])
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  • Childhood obesity predicts adult metabolic syndrome: the Fels Longitudinal Study.
    (Sun SS, et.al. J Pediatr. 2008 Feb;152(2):191-200. Epub 2007 Oct 31.)
    View Abstract
  • The development of porcine models of obesity and the metabolic syndrome.
    (Spurlock ME, et.al. J Nutr. 2008 Feb;138(2):397-402.)
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  • Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome.
    (Aguilera CM, et.al. Clin Sci (Lond). 2008 Feb;114(3):183-93.)
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Other

  • Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam Experience Study.
    (Batty GD, et.al. Diabetologia. 2008 Jan 18; [Epub ahead of print])
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  • Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury.
    (Maruyama Y, et.al. Spinal Cord. 2008 Jan 22; [Epub ahead of print])
    View Abstract
  • AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome.
    (Christ-Crain M, et.al. FASEB J. 2008 Jan 15; [Epub ahead of print])
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  • Elevated gamma-glutamyltransferase activity and perturbed thiol profile are associated with features of metabolic syndrome.
    (Giral P, et.al. Arterioscler Thromb Vasc Biol. 2008 Jan 17; [Epub ahead of print])
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  • Are there specific treatments for the metabolic syndrome?
    (Giugliano D, et.al. Am J Clin Nutr. 2008 Jan;87(1):8-11.)
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Pediatrics/ Metabolic Syndrome in Children

  • Examining metabolic syndrome definitions in overweight Hispanic youth: a focus on insulin resistance.
    (Shaibi GQ, et.al. J Pediatr. 2008 Feb;152(2):171-6. Epub 2007 Oct 22.)
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  • Prevalence and risk factors of metabolic syndrome in obese children and adolescents: the role of the severity of obesity.
    (Sen Y, et.al. Eur J Pediatr. 2008 Jan 17; [Epub ahead of print])
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  • Low-grade inflammation and the metabolic syndrome in children and adolescents.
    (Wärnberg J, et.al. Curr Opin Lipidol. 2008 Feb;19(1):11-15.)
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  • Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): Association with clinical characteristics, beta cell function and cardio-metabolic risk factors.
    (Thai AC, et.al. Diabetes Res Clin Pract. 2008 Jan 17; [Epub ahead of print])
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  • Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents.
    (Nguyen S, et.al. Pediatrics. 2008 Jan;121(1):37-45.)
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  • Metabolic complications of obesity in childhood and adolescence: more than just diabetes.
    (Nathan BM, et.al. Curr Opin Endocrinol Diabetes Obes. 2008 Feb;15(1):21-9.)
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  • Waist circumference correlates with liver fibrosis in children with non alcoholic steatohepatitis.
    (Manco M, et.al. Gut. 2008 Jan 24; [Epub ahead of print])
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Psychiatric Disorders

  • The prevalence of metabolic syndrome among psychiatric inpatients in Brazil.
    (Teixeira PJ, et.al. Rev Bras Psiquiatr. 2007 Dec;29(4):330-336.)
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  • Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder.
    (Shelton RC, et.al. Acta Psychiatr Scand. 2008 Jan 8; [Epub ahead of print])
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  • Seasonal changes in mood and behavior are linked to metabolic syndrome.
    (Rintamäki R, et.al. PLoS ONE. 2008 Jan 23;3(1):e1482.)
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Renal Function / Kidney Disease

  • Correlation of metabolic syndrome with residual renal function, solute transport rate and peritoneal solute clearance in chronic peritoneal dialysis patients.
    (Chen HY, et.al. Blood Purif. 2008 Jan 22;26(2):138-144 [Epub ahead of print])
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  • Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome.
    (Sanchez-Lozada LG, et.al. Am J Physiol Renal Physiol. 2008 Jan 23; [Epub ahead of print])
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  • Metabolic syndrome and kidney disease.
    (Ritz E.Blood Purif. 2008;26(1):59-62. Epub 2008 Jan 10.)
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  • The association of nephrolithiasis with hypertension and obesity: A review.
    (Obligado SH, et.al. Am J Hypertens. 2008 Jan 24; [Epub ahead of print])
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Risk Factors

  • Metabolic syndrome and the risk of new vascular events and all-cause mortality in patients with coronary artery disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm.
    (Wassink AM, et.al. Eur Heart J. 2008 Jan;29(2):213-23.)
    View Abstract
  • Risk factors associated with metabolic syndrome in Korean elderly.
    (Kim MH, et.al. Ann Nutr Metab. 2008 Jan 10;51(6):533-540 [Epub ahead of print])
    View Abstract
  • The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome.
    (Katcher HI, et.al. Am J Clin Nutr. 2008 Jan;87(1):79-90.)
    View Abstract
  • Does the constellation of risk factors with and without abdominal adiposity associate with different cardiovascular mortality risk?
    ([No authors listed]Int J Obes (Lond). 2008 Jan 22; [Epub ahead of print])
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  • Functional capacity and quality of life in middle-age men and women with high and low number of metabolic risk factors.
    (Levinger I, et.al. Int J Cardiol. 2008 Jan 9; [Epub ahead of print])
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Coordinated by Dr. Scott Grundy, Past-President of the IAS