The Metabolic Syndrome Institute Literature Watch features
the latest articles on the metabolic syndrome.
Click on the links below to view the abstracts for each article.

Adiponectin

  • Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity.
    (Hung J, et.al. Int J Obes (Lond). 2008 May;32(5):772-9. Epub 2008 Feb 5.)
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Apo / Lipoproteins

  • Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome.
    (Holvoet P, et.al. JAMA. 2008 May 21;299(19):2287-93.)
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  • Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome.
    (Onat A, et.al. Coron Artery Dis. 2008 May;19(3):125-31.)
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Cancer

  • Metabolic changes during gonadotropin-releasing hormone agonist therapy for prostate cancer: differences from the classic metabolic syndrome.
    (Smith MR, et.al. Cancer. 2008 May 15;112(10):2188-94.)
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Cardiovascular Risk / Cardiovascular Disease

  • Cardiovascular risk assessment in the metabolic syndrome: results from the Prospective Cardiovascular Munster (PROCAM) Study.
    (Assmann G, et.al. Int J Obes (Lond). 2008 May;32 Suppl 2:S11-6.)
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  • Metabolic syndrome does not increase angiographic restenosis rates after drug-eluting stent implantation.
    (Canibus P, et.al. Metabolism. 2008 May;57(5):593-7.)
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  • The metabolic syndrome and cardiovascular risk: implications for clinical practice.
    (Eddy DM, et.al. Int J Obes (Lond). 2008 May;32 Suppl 2:S5-10.)
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  • The relative risk of cardiovascular death among racial and ethnic minorities with metabolic syndrome: data from the NHANES-II mortality follow-up.
    (Martins D, et.al. J Natl Med Assoc. 2008 May;100(5):565-71.)
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  • Determining the relationship between metabolic syndrome score and angiographic severity of coronary artery disease.
    (Yavuz B, et.al. Int J Clin Pract. 2008 May;62(5):717-22. Epub 2008 Feb 7.)
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  • The metabolic syndrome and cardiovascular risk in the British Regional Heart Study.
    (Wannamethee SG.Int J Obes (Lond). 2008 May;32 Suppl 2:S25-9.)
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  • The metabolic syndrome increases cardiovascular mortality in Taiwanese elderly.
    (Wen CJ, et.al. Eur J Clin Invest. 2008 May 21. [Epub ahead of print])
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  • Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study.
    (Mozaffarian D, et.al. Arch Intern Med. 2008 May 12;168(9):969-78.)
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  • All-cause mortality risk predictors in a preventive cardiology clinic cohort-examining diabetes and individual metabolic syndrome criteria: a PRECIS database study.
    (Doshi KB, et.al. Diabetes Obes Metab. 2008 May 20. [Epub ahead of print])
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Defining the Metabolic Syndrome

  • The metabolic syndrome and incident diabetes: Assessment of alternative definitions of the metabolic syndrome in an Iranian urban population.
    (Hadaegh F, et.al. Diabetes Res Clin Pract. 2008 May;80(2):328-34. Epub 2008 Feb 20.)
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  • Should liver function tests be included in definitions of metabolic syndrome? Evidence from the association between liver function tests, components of metabolic syndrome and prevalent cardiovascular disease.
    (Devers MC, et.al. Diabet Med. 2008 May;25(5):523-9. Epub 2008 Mar 13.)
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  • National Cholesterol Education Program and International Diabetes Federation definitions of metabolic syndrome in the prediction of diabetes. Results from the FIrenze-Bagno A Ripoli study.
    (Mannucci E, et.al. Diabetes Obes Metab. 2008 May;10(5):430-5. Epub 2007 Apr 5.)
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  • The impact of the components of metabolic syndrome on heart rate variability: using the NCEP-ATP III and IDF definitions.
    (Min KB, et.al. Pacing Clin Electrophysiol. 2008 May;31(5):584-91.)
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  • The relationship of three common definitions of the metabolic syndrome with sub-clinical carotid atherosclerosis.
    (Paras E, et.al. Atherosclerosis. 2008 May;198(1):228-36. Epub 2007 Oct 23.)
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  • Prevalence of metabolic syndrome at age 16 using the International Diabetes Federation paediatric definition.
    (Pirkola J, et.al. Arch Dis Child. 2008 May 2. [Epub ahead of print])
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  • Optimal cutoff point of waist circumference and use of home blood pressure as a definition of metabolic syndrome: the ohasama study.
    (Sato A, et.al. Am J Hypertens. 2008 May;21(5):514-20. Epub 2008 Mar 6.)
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Diabetes

  • One hour plasma glucose concentration and the metabolic syndrome identifies subjects at high risk for future type 2 diabetes.
    (Abdul-Ghani MA, et.al. Diabetes Care. 2008 May 16. [Epub ahead of print])
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  • Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu,China of 5 years follow-up.
    (Liu SJ, et.al. Diabetes Res Clin Pract. 2008 May 14. [Epub ahead of print])
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  • Prevalence of diabetes mellitus and metabolic syndrome in Slovakia.
    (Mokán( M, et.al. Diabetes Res Clin Pract. 2008 May 19. [Epub ahead of print])
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Diet, Nutrition and Metabolism

  • High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men.
    (Kume A, et.al. Diabetes Res Clin Pract. 2008 May;80(2):259-64. Epub 2008 Feb 1.)
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  • Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome.
    (Macfarlane DP, et.al. J Endocrinol. 2008 May;197(2):189-204.)
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  • Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease.
    (Pasinetti GM, et.al. J Neurochem. 2008 May 3. [Epub ahead of print])
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  • Dietary fat, sedentary behaviors and the prevalence of the metabolic syndrome among Qingdao adults.
    (Chen X, et.al. Nutr Metab Cardiovasc Dis. 2008 May 8. [Epub ahead of print])
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  • Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women.
    (Konstantinova SV, et.al. J Nutr. 2008 May;138(5):914-20.)
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  • Sex may modify the effects of macronutrient intake on metabolic syndrome and insulin resistance in American Indians: the strong heart study.
    (Eilat-Adar S, et.al. J Am Diet Assoc. 2008 May;108(5):794-802.)
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  • Prospective study of alcohol consumption and metabolic syndrome.
    (Baik I, et.al. Am J Clin Nutr. 2008 May;87(5):1455-63.)
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  • ChREBP: A glucose-activated transcription factor involved in the development of metabolic syndrome.
    (Iizuka K, et.al. Endocr J. 2008 May 19. [Epub ahead of print])
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  • Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome.
    (Kallio P, et.al. Am J Clin Nutr. 2008 May;87(5):1497-503.)
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  • Neurobiology of the metabolic syndrome: An allostatic perspective.
    (van Dijk G, et.al. Eur J Pharmacol. 2008 May 6;585(1):137-46. Epub 2008 Mar 4.)
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  • The metabolic syndrome in relation with the glycemic index and the glycemic load.
    (Vrolix R, et.al. Physiol Behav. 2008 May 23;94(2):293-9. Epub 2007 Dec 8.)
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  • Fat overload aggravates oxidative stress in patients with the metabolic syndrome.
    (Cardona F, et.al. Eur J Clin Invest. 2008 May 16. [Epub ahead of print])
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Drug Therapy

  • Prevalence and associations of the metabolic syndrome among patients prescribed clozapine.
    (Ahmed M, et.al. Ir J Med Sci. 2008 May 7. [Epub ahead of print])
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  • High doses of lercanidipine are better tolerated than other dihydropyridines in hypertensive patients with metabolic syndrome: results from the TOLERANCE study.
    (Barrios V, et.al. Int J Clin Pract. 2008 May;62(5):723-8. Epub 2008 Mar 17.)
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  • Rimonabant in rats with a metabolic syndrome: good news after the depression.
    (Di Marzo V, et.al. Br J Pharmacol. 2008 May 5. [Epub ahead of print])
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  • Dose-dependent effect of rosuvastatin on very-low density lipoprotein- apolipoprotein C-III kinetics in the metabolic syndrome.
    (Ooi EM, et.al. Diabetes Care. 2008 May 28. [Epub ahead of print])
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  • Allopurinol improves endothelial function and reduces oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome.
    (Yiginer O, et.al. Clin Res Cardiol. 2008 May;97(5):334-40. Epub 2007 Dec 28.)
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  • Peroxisome proliferator-activated receptors and the metabolic syndrome.
    (Bragt MC, et.al. Physiol Behav. 2008 May 23;94(2):187-197. Epub 2007 Dec 7.)
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Epidemiology

  • Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation.
    (Annaloro C, et.al. Bone Marrow Transplant. 2008 May;41(9):797-804. Epub 2008 Jan 14.)
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  • Relationship of serum resistin level to traits of metabolic syndrome and serum paraoxonase 1 activity in a population with a broad range of body mass index.
    (Bajnok L, et.al. Exp Clin Endocrinol Diabetes. 2008 May 9. [Epub ahead of print])
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  • Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese.
    (Cheung BM, et.al. Clin Endocrinol (Oxf). 2008 May;68(5):730-7. Epub 2007 Nov 2.)
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  • Prevalence of metabolic syndrome in retired National Football League players.
    (Miller MA, et.al. Am J Cardiol. 2008 May 1;101(9):1281-4. Epub 2008 Mar 7.)
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  • Evaluation of metabolic syndrome in adults of Talca city, Chile.
    (Mujica V, et.al. Nutr J. 2008 May 15;7:14.)
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Genetics

  • Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndrome.
    (Bi XP, et.al. Endocr J. 2008 May 23. [Epub ahead of print])
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  • Association of ENPP1 (PC-1) K121Q polymorphism with obesity-related parameters in subjects with metabolic syndrome.
    (González-Sánchez JL, et.al. Clin Endocrinol (Oxf). 2008 May;68(5):724-9. Epub 2007 Nov 6.)
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  • Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
    (Ridker PM, et.al. Am J Hum Genet. 2008 May;82(5):1185-92. Epub 2008 Apr 24.)
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  • Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome.
    (Tassi V, et.al. Nutr Metab Cardiovasc Dis. 2008 May;18(4):263-70. Epub 2007 Jun 18.)
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  • A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome.
    (Wong J, et.al. Diabetes Res Clin Pract. 2008 May;80(2):203-7. Epub 2008 Jan 3.)
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  • Overindulgence and metabolic syndrome: is FoxO1 a missing link?
    (Sparks JD, et.al. J Clin Invest. 2008 May 22. [Epub ahead of print])
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  • The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women.
    (Jang Y, et.al. Clin Chim Acta. 2008 May;391(1-2):85-90. Epub 2008 Feb 16.)
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  • Interleukin-15 and interleukin-15Ralpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome.
    (Pistilli EE, et.al. Cytokine. 2008 May 29. [Epub ahead of print])
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Hypertension

  • Effect of metabolic syndrome or type II diabetes mellitus on the occurrence of recurrent vascular events in hypertensive patients.
    (Vlek AL, et.al. J Hum Hypertens. 2008 May;22(5):358-65. Epub 2008 Feb 14.)
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  • Different BMI cardiovascular risk thresholds as markers of organ damage and metabolic syndrome in primary hypertension.
    (Litwin M, et.al. Pediatr Nephrol. 2008 May;23(5):787-796. Epub 2008 Feb 6.)
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  • Renin-angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans.
    (Sarzani R, et.al. J Hypertens. 2008 May;26(5):831-43.)
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  • Metabolic syndrome and vascular reactivity.
    (Ferrara LA.Int J Cardiol. 2008 May 23;126(2):274-275. Epub 2007 Jul 24.)
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Kidney Disease

  • PPARs and the kidney in metabolic syndrome.
    (Ruan X, et.al. Am J Physiol Renal Physiol. 2008 May;294(5):F1032-47. Epub 2008 Jan 30.)
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  • Metabolic syndrome and self-reported history of kidney stones: the National Health and Nutrition Examination Survey (NHANES III) 1988-1994.
    (West B, et.al. Am J Kidney Dis. 2008 May;51(5):741-7. Epub 2008 Mar 20.)
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  • Metabolic syndrome, proteinuria, and the risk of progressive CKD in hypertensive African Americans.
    (Lea J, et.al. Am J Kidney Dis. 2008 May;51(5):732-40. Epub 2008 Mar 20.)
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Markers

  • Is serum cystatin-C a reliable marker for metabolic syndrome?
    (Servais A, et.al. Am J Med. 2008 May;121(5):426-32.)
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  • CRP and adiponectin and its oligomers in the metabolic syndrome: evaluation of new laboratory-based biomarkers.
    (Devaraj S, et.al. Am J Clin Pathol. 2008 May;129(5):815-22.)
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  • Inflammatory markers in relation to insulin resistance and the metabolic syndrome.
    (Ingelsson E, et.al. Eur J Clin Invest. 2008 May 16. [Epub ahead of print])
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Metabolic Syndrome in Men

  • Association among metabolic syndrome, testosterone level and severity of erectile dysfunction.
    (Yeh HC, et.al. Kaohsiung J Med Sci. 2008 May;24(5):240-7.)
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  • The triad of erectile dysfunction, hypogonadism and the metabolic syndrome.
    (Shabsigh R, et.al. Int J Clin Pract. 2008 May;62(5):791-8. Epub 2008 Feb 2.)
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  • Metabolic syndrome in men with Klinefelter's Syndrome.
    (Ishikawa T, et.al. Urology. 2008 May 1. [Epub ahead of print])
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  • The metabolic syndrome and male infertility.
    (Kasturi SS, et.al. J Androl. 2008 May-Jun;29(3):251-9. Epub 2008 Jan 24.)
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Metabolic Syndrome in Women

  • Metabolic syndrome in postmenopausal women: the influence of oral or transdermal estradiol on inflammation and coagulation markers.
    (Chu MC, et.al. Am J Obstet Gynecol. 2008 May 27. [Epub ahead of print])
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  • Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome.
    (Joon Cho G, et.al. Menopause. 2008 May-Jun;15(3):524-9.)
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Non-Alcholic Fatty Liver Disease

  • Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease.
    (Aygun C, et.al. Dig Dis Sci. 2008 May;53(5):1352-7. Epub 2007 Oct 16.)
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Obesity

  • Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome.
    (Bingham NC, et.al. Endocrinology. 2008 May;149(5):2138-48. Epub 2008 Feb 7.)
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Pediatrics

  • Impact of childhood metabolic syndrome components on the risk of elevated uric Acid in adulthood: the bogalusa heart study.
    (Muntner P, et.al. Am J Med Sci. 2008 May;335(5):332-7.)
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  • C-reactive protein and metabolic syndrome in youth: A strong relationship?
    (Oliveira AC, et.al. Obesity (Silver Spring). 2008 May;16(5):1094-8. Epub 2008 Mar 6.)
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  • Prevalence of the metabolic syndrome among urban schoolchildren in Sousse, Tunisia.
    (Harrabi I, et.al. Int J Cardiol. 2008 May 19. [Epub ahead of print])
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  • Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms.
    (Syme C, et.al. Arch Pediatr Adolesc Med. 2008 May;162(5):453-61.)
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  • Independent effect of visceral adipose tissue on metabolic syndrome in obese adolescents.
    (Druet C, et.al. Horm Res. 2008 May 20;70(1):22-28. [Epub ahead of print])
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Risk Factors

  • Metabolic syndrome risk for cardiovascular disease and diabetes in the ARIC study.
    (Ballantyne CM, et.al. Int J Obes (Lond). 2008 May;32 Suppl 2:S21-4.)
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  • The association of the metabolic syndrome with QTc interval in NHANES III.
    (Faramawi MF, et.al. Eur J Epidemiol. 2008 May 29. [Epub ahead of print])
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  • Relationship between serum free thyroxine levels and metabolic syndrome and its components in healthy euthyroid subjects.
    (Kim BJ, et.al. Clin Endocrinol (Oxf). 2008 May 20. [Epub ahead of print])
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  • Metabolic syndrome and three of its components as risk factors for recurrent ischaemic stroke presenting as large-vessel infarction.
    (Liou CW, et.al. Eur J Neurol. 2008 May 27. [Epub ahead of print])
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  • Metabolic syndrome - risk factors for atherosclerosis and diabetes.
    (Mihic M, et.al. Curr Diabetes Rev. 2008 May;4(2):122-8.)
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  • Mild gestational hyperglycaemia as a risk factor for metabolic syndrome in pregnancy and adverse perinatal outcomes.
    (Negrato CA, et.al. Diabetes Metab Res Rev. 2008 May;24(4):324-30.)
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  • Metabolic syndrome associated with toenail onychomycosis in Taiwanese with diabetes mellitus.
    (Chang SJ, et.al. Int J Dermatol. 2008 May;47(5):467-72.)
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  • Metabolic syndrome and inflammatory responses to long-term particulate air pollutants.
    (Chen JC, et.al. Environ Health Perspect. 2008 May;116(5):612-7.)
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  • Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications.
    (Sidiropoulos PI, et.al. Arthritis Res Ther. 2008 May 8;10(3):207. [Epub ahead of print])
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  • Influence of uric acid and gamma-glutamyltransferase on total antioxidant capacity and oxidative stress in patients with the metabolic syndrome.
    (Simăo AN, et.al. Nutrition. 2008 May 20. [Epub ahead of print])
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  • Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection.
    (Hanouneh IA, et.al. Clin Gastroenterol Hepatol. 2008 May;6(5):584-9.)
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Screening & Diagnosis

  • Usefulness of microalbuminuria versus the metabolic syndrome as a predictor of cardiovascular disease in women and men>40 years of age (from the Rancho Bernardo Study).
    (Jassal SK, et.al. Am J Cardiol. 2008 May 1;101(9):1275-80. Epub 2008 Mar 7.)
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  • Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies.
    (Sattar N, et.al. Lancet. 2008 May 21. [Epub ahead of print])
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  • Why metabolic syndrome criteria have not made prime time: a view from the clinic.
    (Sattar N.Int J Obes (Lond). 2008 May;32 Suppl 2:S30-4.)
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  • MRI total sagittal abdominal diameter as a predictor of metabolic syndrome compared to visceral fat at L4-L5 level.
    (Valsamakis G, et.al. Curr Med Res Opin. 2008 May 27. [Epub ahead of print])
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Sleep Disorders

  • Relationship between sleep duration and the metabolic syndrome: Korean National Health and Nutrition Survey 2001.
    (Choi KM, et.al. Int J Obes (Lond). 2008 May 13. [Epub ahead of print])
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Stroke

  • Metabolic syndrome is associated with silent ischemic brain lesions.
    (Bokura H, et.al. Stroke. 2008 May;39(5):1607-9. Epub 2008 Mar 6.)
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  • Association between metabolic syndrome and risk of stroke: A meta-analysis of cohort studies.
    (Li W, et.al. Cerebrovasc Dis. 2008 May 15;25(6):539-547. [Epub ahead of print])
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Vascular Biology

  • Intravascular kinetics of C-reactive protein and their relationships with features of the metabolic syndrome.
    (Mauger JF, et.al. J Clin Endocrinol Metab. 2008 May 20. [Epub ahead of print])
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  • The role of urotensin II in the metabolic syndrome.
    (Ong KL, et.al. Peptides. 2008 May;29(5):859-67. Epub 2007 Jun 8.)
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  • Glycation does not modify bovine serum albumin (BSA)-induced reduction of rat aortic relaxation. The response to glycated and non-glycated BSA is lost in metabolic syndrome.
    (Rubio-Ruiz ME, et.al. Glycobiology. 2008 May 5. [Epub ahead of print])
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  • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.
    (Zhang X, et.al. Diabetes. 2008 May;57(5):1246-53. Epub 2008 Feb 5.)
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Coordinated by Dr. Scott Grundy, Past-President of the IAS