MSI Slide Kit Update:
PPAR: Role in Lipid Disorder Correction



Download the MSI Slide Kit

Slide Kit part 1:
The Main Threat To Human Health For The Next Decade

Slide Kit part 2:
The Double Jeopardy of the Metabolic Syndrome

Slide Kit part 3:
Defusing the Metabolic Time Bomb

Slide Kit part 4:
Combating the Metabolic Syndrome: Action Plan

Slide Kit part 5:
Metabolic Syndrome and Insulin Resistance

Slide Kit part 6:
The Metabolic Syndrome - A Reversible Life-Threatening Condition


Metabolic Syndrome News
(from April 2008)

Epidemiology

Obesity associated with increased risk of developing stage 3 chronic kidney disease
(Posted May 29, 2008) | View

Risk of coronary heart disease associated with elevated BMI considerably reduced by increased physical activity
(Posted May 28, 2008) | View

Differences in diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations
(Posted May 23, 2008) | View

Mild retinopathy signs as a preclinical marker of underlying microvascular disease and future diabetes risk
(Posted May 16, 2008) | View

Psychosocial deprivation as an independent determinant of metabolic syndrome in a Paris suburb
(Posted May 13, 2008) | View

Higher prevalence of metabolic syndrome and increased Framingham risk scores in women with bilateral oophorectomy before 50 years of age
(Posted May 12, 2008) | View

Requirement for glucose-lowering therapy should prompt intensive prophylactic treatment for cardiovascular diseases
(Posted May 8, 2008) | View

Significant increase of overweight and obesity during the 1990s in China
(Posted May 7, 2008) | View

Obesity associated to an increased risk of aeroallergen sensitization and allergic asthma
(Posted May 6, 2008) | View

Eating meals irregularly as a novel risk factor for metabolic syndrome
(Posted May 5, 2008) | View

 
Pathophysiological Aspects

Intra-abdominal fat may be a key determinant in the development of larger aortic diameters
(Posted May 26, 2008) | View

Obesity only weakly related to traditional cardiovascular risk factors in black South African women
(Posted May 20, 2008) | View

Inverse association of 25-hydroxyvitamin D and positive association of parathyroid hormone levels with metabolic syndrome among US adults
(Posted May 19, 2008) | View

Metabolic syndrome factors as important accelerators for type 2 diabetes in the Anglo-Celtic but not in the Chinese population
(Posted May 9, 2008) | View

Metabolic syndrome independently associated with the presence and extent of coronary atherosclerotic plaques
(Posted May 2, 2008) | View

 
Metabolic Syndrome Components / Risk Factors / Associated Risks
(HIGH BLOOD PRESSURE)
Leanness as a significant determinant of poor cognitive function in hypertensive elderly patients
(Posted May 27, 2008) | View

(ABDOMINAL OBESITY)
The simple message: “Keep your waist circumference to less than half your height”
(Posted May 14, 2008) | View

 
Prevention and Treatment

Caloric restriction with or without exercise shown to reduce oxidative stress in obese patients with type 2 diabetes
(Posted May 30, 2008) | View

Calorie restriction reduces liver lipids in overweight subjects without non-alcoholic fatty liver disease
(Posted May 22, 2008) | View

A randomized controlled trial comparing the physiological response to 10 weeks of combined aerobic and resistance exercise versus exercise + minimal nutrition intervention in overweight adults
(Posted May 21, 2008) | View

Adherence to the DASH-style diet associated with a lower risk of coronary heart disease and stroke in women
(Posted May 15, 2008) | View


Featured Upcoming Congresses
(July - December 2008)

3rd International Symposium on Integrated Biomarkers in Cardiovascular Disease
Date:
  July 9-11, 2008
Location:
  Seattle, WA
Website:
  http://www.ibcvd.org/home.aspx
 
Australian Diabetes Society / ADEA Annual Scientific Meeting
Date:
  August 28-30, 2008
Location:
  Melbourne, Australia
Website:
  http://www.racp.edu.au/ads/meetings.htm
 
ESC Congress 2008
Date:
  August 30-September 3, 2008
Location:
  Munich, Germany
Website:
  http://www.escardio.org
 
2008 Cardiometabolic Health Congress
Date:
  October 15-18, 2008
Location:
  Boston, MA
Website:
 

http://www.cardiometabolichealth.org/

 
1st Diabetes in Asia Study Group Conference
Date:
  October 16-19, 2008
Location:
  Kathmandu, Nepal
Website:
  http://dasg.dapkhi.org/Default.aspx
 
2nd World Congress on Controversies in Diabetes, Obesity and hypertension (CODHy)
Date:
  October 30-November 2, 2008
Location:
  Barcelona, Spain
Website:
  http://www.codhy.com/2008/
 
XV International Symposium on Atherosclerosis
Date:
  June 14-18, 2009
Location:
  Boston, MA, USA
Website:
  http://www.isa2009.org/


Ongoing Trials With Lifestyle and Obesity Management
(Prevention of Cardiovascular Events)

Trial - GOSPEL
GlObal Secondary Prevention strategiEs to Limit event recurrence after myocardial infarction

Outcome: Cardiovascular mortality, non fatal re-MI, angina requiring hospitalization, urgent revascularization procedures, hospitalization for heart failure, non fatal stroke.

Expected total enrollment: 3241 patients with recent (<3 months) myocardial infarction who completed an initial cardiac rehabilitation programme.

Comparisons: Long-lasting (over 3 years) multifactorial continued educational and behavioural programme (extensive cardiac rehabilitation sessions, monthly from months 1 to 6, then every 6 months for 3 years with aerobic exercise, comprehensive lifestyle and risk factor counseling, and clinical assessment) vs usual care.

Design: Randomized, open label, active control, parallel assignment.


> View all landmark studies and clinical trials


Framingham Risk Assessment Tool
Estimates 10-year risk of developing hard CHD
> View Tool

Procam Risk Calculator
Estimates your risk of a heart attack (myocardial infarction) within the next 10 years based upon data of the PROCAM Study
> View Calculator


SCORE
(European High Risk Chart)

Estimates 10 year risk of fatal CVD in high risk regions of Europe by gender, age, systolic blood pressure, total cholesterol and smoking status.
> View Chart

UKPDS Risk Engine
The UKPDS Risk Engine is a type 2 diabetes specific risk calculator based on 53,000 patients years of data from the UK Prospective Diabetes Study, which also provides an approximate 'margin of error' for each estimate.
> View Risk Engine


Mission of the Metabolic
Syndrome Institute

Created in 2003, the Metabolic Syndrome Institute is an independent and not for profit association. Its members are international experts in lipid metabolism, diabetes, heart disease, endocrinology obesity, genetics, epidemiology, basic research and health economics. Being the first association totally devoted to the dissemination of knowledge about the metabolic syndrome, the Metabolic Syndrome Institute will provide an international multidisciplinary approach to a worldwide public health problem.

 
Contact Metabolic Syndrome Institute
212, avenue Paul Doumer
92500 Rueil-Malmaison Cedex
FRANCE
Phone: (33) 1 41 42 20 35
Fax: (33) 1 41 42 20 01
Email:

contact@metabolic-syndrome-institute.org
Website:
http://www.metabolic- syndrome-institute.org

     
Coordinated by Dr. Scott Grundy, Past-President of the IAS